肾结核患者血清YKL-40、miR-361-5p表达与预后的相关性  

Serum YKL-40 and miR-361-5p expression and correlation with prognosis in renal tuberculosis patients

作　　者：赵艳微 宋清玲 龚晓磊 李玮 ZHAO Yanwei;SONG Qingling;GONG Xiaolei;LI Wei(Department of Laboratory Medicine,The 980 th Hospital of PLA Joint Logistic Support Force,Shijiazhuang 050082,Hebei,China)

机构地区：[1]中国人民解放军联勤保障部队第九八〇医院检验科,河北石家庄050082 [2]联勤保障部队临潼康复疗养中心病理科,陕西西安710699 [3]石家庄赵县人民医院感控科,河北石家庄051530

出　　处：《皖南医学院学报》2025年第2期129-132,共4页Journal of Wannan Medical College

基　　金：河北省医学科学研究课题(20201020)。

摘　　要：目的:探究肾结核患者血清人类软骨糖蛋白39(YKL-40)、微小核糖核酸-361-5p(miR-361-5p)表达状况,并分析该两项指标与患者预后的相关性。方法:纳入2020年1月~2023年4月中国人民解放军联勤保障部队第九八〇医院完成6个月随访的85例肾结核患者为研究对象,记录患者预后情况,并将其分为预后不良组与预后良好组,所有患者入院时均接受血清YKL-40、miR-361-5p检测,对比两组基线资料及血清YKL-40、miR-361-5p水平,分析肾结核患者入院时血清YKL-40、miR-361-5p水平与预后的相关性,并绘制受试者工作特征曲线(ROC)探讨两者对肾结核患者预后的预测价值。结果:随访6个月,85例肾结核患者中预后不良13例(15.29%),预后良好72例(84.71%);预后不良组Cr、YKL-40、miR-361-5p水平均高于预后良好组(P<0.05);血清YKL-40、miR-361-5p水平与肾结核患者预后呈正相关(r=0.396、0.456,P<0.05);COX回归分析结果显示,血清YKL-40(95%CI:1.024~1.162)、miR-361-5p(95%CI:2.129~14.089)水平是肾结核患者预后不良的危险因素(P<0.05);ROC曲线显示,血清YKL-40(AUC=0.826,95%CI:0.712~0.939)、miR-361-5p(AUC=0.816,95%CI:0.702~0.930)水平对肾结核患者预后具有一定预测价值,联合检测预测价值更高(AUC=0.873,95%CI:0.786~0.960)。结论:肾结核患者血清YKL-40、miR-361-5p表达与预后密切相关,可用于预测肾结核患者预后。Objective:To observe the expression levels of serum human cartilage glycoprotein 39(YKL-40)and microRNA-361-5p(miR-361-5p)in renal tuberculosis patients,and analyze the correlation between these two indicators and patient prognosis.Methods:Eighty-five patients with renal tuberculosis who underwent 6-month follow-up from January 2020 to April 2023 in the 980 th Hospital of the Chinese People′s Liberation Army Joint Logistic Support Force were included as the study objects.The prognosis was recorded,and by which the patients were divided into poor prognosis group and good prognosis group.All patients underwent serum YKL-40 and miR-361-5p testing upon admission,and the baseline data as well as serum levels of YKL-40 and miR-361-5p were compared between the two groups.The correlation between serum levels of YKL-40 and miR-361-5p at admission and patients′prognosis was analyzed,and the receiver operating characteristic(ROC)curve was used to assess the predictive value of these two indicators for the prognosis of renal tuberculosis patients.Results:In the 85 patients included in current observation,poor prognosis was seen in 13(15.29%),and good prognosis in 72(84.71%).The levels of Cr,YKL-40,and miR-361-5p in the poor prognosis group were all higher than those in the good prognosis group(t=2.687,3.926,4.706,respectively,P<0.05).The serum levels of YKL-40 and miR-361-5p were positively correlated with patients′prognosis(r=0.396 and 0.456,respectively,P<0.05).Cox regression analysis showed that serum levels of YKL-40(95%CI:1.024-1.162)and miR-361-5p(95%CI:2.129-14.089)were risk factors for poor prognosis in renal tuberculosis patients(P<0.05).The ROC curve analysis revealed that serum levels of YKL-40(AUC:0.826,95%CI:0.712-0.939)and miR-361-5p(AUC:0.816,95%CI:0.702-0.930)had certain predictive value for the prognosis of patients with renal tuberculosis.The predictive value was higher when the indicators aforementioned were jointly detected(AUC:0.873,95%CI:0.786-0.960).Conclusion:The expression of serum YKL-40 and m

关 键 词：肾结核 人类软骨糖蛋白39 微小核糖核酸-361-5p 预后 

分 类 号：R446.11[医药卫生—诊断学] R527.1[医药卫生—临床医学]