ZJU指数、METS-IR指数及TyG-BMI指数预测代谢相关脂肪性肝病价值的比较  

Comparison of ZJU,METS-IR and TyG-BMI indexes in predicting the incidence of metabolic-associated fatty liver disease

作　　者：武艳 董奥奇 张先翠 王箴 徐艳 WU Yan;DONG Aoqi;ZHANG Xiancui;WANG Zhen;XU Yan(Graduate School,Wannan Medical College,Wuhu 241002,Anhui,China)

机构地区：[1]皖南医学院研究生学院,安徽芜湖241002 [2]皖南医学院第一附属医院弋矶山医院健康管理中心,安徽芜湖241001 [3]皖南医学院第一附属医院弋矶山医院人事科,安徽芜湖241001

出　　处：《皖南医学院学报》2025年第2期133-137,共5页Journal of Wannan Medical College

基　　金：安徽省高等学校自然科学研究项目(2022AH040165)。

摘　　要：目的:探讨浙江大学指数(ZJU指数)、胰岛素抵抗代谢评分指数(METS-IR指数)及甘油三酯-葡萄糖-体质量指数(TyG-BMI指数)对代谢相关脂肪性肝病(MAFLD)预测价值的比较。方法:回顾性选取2023年7~12月弋矶山医院的28280例体检者为研究对象,通过腹部超声和生化指标检测评估MAFLD,分为非MAFLD组(19069例)和MAFLD组(9211例),比较两组间各指标差异,采用Logistic回归分析明确ZJU指数、METS-IR指数及TyG-BMI指数是否为MAFLD的影响因素,通过受试者工作特征曲线(ROC)进一步分析其在MAFLD筛查中的预测价值。结果:METS-IR指数(OR=1.151,95%CI:1.128~1.174)、ZJU指数(OR=1.099,95%CI:1.077~1.121)、TyG-BMI指数(OR=1.026,95%CI:1.022~1.031)升高均是MAFLD发生的危险因素(P<0.05)。METS-IR指数、TyG-BMI指数、ZJU指数及三者联合预测的AUC分别为0.896、0.895、0.883、0.900。结论:ZJU指数、METS-IR指数及TyG-BMI指数均是MAFLD患者发病的危险因素,可预测疾病的发生,三者联合预测价值最高。Objective:To compare the outcomes of Zhejiang University Index(ZJU Index),Metabolic Score for Insulin Resistance(METS-IR Index),and Triglyceride-Glucose(TyG)-BMI Index in estimating metabolic-associated fatty liver disease(MAFLD).Methods:A retrospective study was conducted on 28280 participants who underwent physical examinations at the First Affiliated Hospital of Wannan Medical College from July to December 2023.The participants underwent assessment for MAFLD through abdominal ultrasonography and biochemical indicators from laboratory studies,and then divided into non-MAFLD group(n=19069)and MAFLD group(n=9211).The differences in various indicators were compared between groups.Logistic regression model was used to verify whether ZJU,METS-IR and TyG-BMI indexes were the factors affecting MAFLD.The predictive value of these indices in MAFLD screening was further analyzed using Receiver Operating Characteristic(ROC)curves.Results:Elevated METS-IR index(OR=1.151,95%CI:1.128-1.174),ZJU index(OR=1.099,95%CI:1.077-1.121),and TyG-BMI index(OR=1.026,95%CI:1.022-1.031)were all risk factors for the occurrence of MAFLD(P<0.05).The AUCs for METS-IR index,TyG-BMI index,ZJU index,and their combined prediction were 0.896,0.895,0.883,and 0.900 respectively.Conclusion:The three indexes are the risk factors for the onset of MAFLD,and can be used to estimate the occurrence of this entity.Nevertheless,combined application of the three indices can be the highest predictive value for occurrence of MAFLD.

关 键 词：代谢性脂肪性肝病 甘油三酯 胰岛素抵抗 预测 

分 类 号：R445.1[医药卫生—影像医学与核医学] R575.5[医药卫生—诊断学]