从中西医不同角度探讨原发性干燥综合征合并慢性萎缩性胃炎的发生机制  

Mechanisms of Sjögren’s syndrome complicated with chronic atrophic gastritis from the perspectives of traditional Chinese medicine and western medicine

作　　者：李端 何晓瑾[1] LI Duan;HE Xiaojin(Nanjing University of Chinese Medicine,Jiangsu,Nanjing 210023,China)

机构地区：[1]南京中医药大学,江苏南京210023

出　　处：《中国医药科学》2025年第7期35-39,共5页China Medicine And Pharmacy

基　　金：江苏省高校“青蓝工程”优秀教学团队项目;江苏省研究生实践创新计划项目(SJCX23_0891)。

摘　　要：原发性干燥综合征(pSS)是一种慢性炎症性自身免疫病,除有唾液腺、泪腺功能受损,亦可出现多系统多器官受累。通过检索对比近年国内外文献发现,目前对pSS合并消化系统受累的研究缺乏重视。文章介绍了中医关于干燥综合征合并慢性萎缩性胃炎(CAG)的病因病机认识,发掘自身免疫病与中医脾胃的内在联系;以及西医学关于CAG的相关发病机制,指出幽门螺杆菌感染、唾液表皮生长因子分泌减少、胃肠动力障碍以及药物不良反应对该病的潜在影响,旨在为临床防治pSS系统受累提供思路。Primary Sjögren’s syndrome(pSS)is a chronic inflammatory autoimmune disease characterized by impaired function of salivary and lacrimal glands,as well as potential multi-system and multi-organ involvement.A review of recent domestic and international literature reveals a lack of emphasis on research regarding pSS complicated with digestive system involvement.This article elu cidates the etiology and pathogenesis of Sjögren’s syndrome complicated with chronic atrophic gastritis(CAG)from the perspective of traditional Chinese medicine(TCM),exploring the intrinsic relationship between autoimmune diseases and the spleen-stomach system in TCM theory.Additionally,it discusses the pathogenesis of this condition from the perspective of Western medicine,highlighting the potential impacts of Helicobacter pylori infection,reduced salivary epidermal growth factor secretion,gastrointestinal motility disorders,and adverse drug reactions.The aim is to provide insights for the clinical prevention and treatment of systemic involvement in pr imary Sjögren’s syndrome.

关 键 词：原发性干燥综合征 慢性萎缩性胃炎 中医学 西医学 病机 

分 类 号：R593.2[医药卫生—内科学] R573.32[医药卫生—临床医学]