中医药干预Wnt信号通路治疗结直肠腺瘤的研究进展  

Research progress on traditional Chinese medicine intervention of Wnt signaling pathway in the treatment of colorectal adenomas

作　　者：陈泽明 王璐[1] 王培[1] 黄楚月 崔经纬 赖杰杨 夏文婷 樊志敏[1] CHEN Zemin;WANG Lu;WANG Pei;HUANG Chuyue;CUI Jingwei;LAI Jieyang;XIA Wenting;FAN Zhimin(Clinical Medical Innovation Center for Colorectal Diseases,Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Jiangsu,Nanjing 210022,China)

机构地区：[1]南京中医药大学附属南京中医院肛肠疾病临床医学创新中心,江苏南京210022

出　　处：《中国医药科学》2025年第7期44-47,共4页China Medicine And Pharmacy

基　　金：江苏省重点研发计划(社会发展)项目(BE2021611);江苏省研究生科研与实践创新计划项目(SJCX24_1099)。

摘　　要：本文对中医药干预无翅相关整合位点(Wnt)信号通路治疗结直肠腺瘤(CRA)进行研究,当Wnt信号通路受到异常激活时,可引起β-连环蛋白(β-catenin)在细胞核内明显积累,上皮细胞过度增殖,导致CRA的发生;中药单体及复方可通过调控Wnt信号通路相关蛋白Wnt配体、腺瘤性结肠息肉(APC)、β-catenin水平以及抑制Wnt信号通路的活化,达到抑制CRA复发及发展的目的。本文综述中医学对CRA的认识、中药治疗CRA的研究进展、Wnt信号通路与CRA的关系及中医药通过Wnt信号通路防治CRA的相关研究,旨在为防治CRA提供有力依据,为中医药治疗CRA提供新策略。This article studies the intervention of traditional Chinese medicine(TCM)in the treatment of colorectal adenoma(CRA)with wingless-related integration site(Wnt)signaling pathway.When the Wnt signaling pathway is abnormally activated,it can cause significant accumulation ofβ-catenin in the nucleus,leading to excessive proliferation of epithelial cells and the occurrence of CRA.Chinese herbal monomers and formulas can achieve the goal of inhibiting CRA recurrence and development by regulating Wnt signaling pathway related proteins Wnt ligands,adenomatous polyposis coli(APC),β-catenin levels,and inhibiting the activation of Wnt signaling pathway.This article reviews the understanding of TCM on CRA,the research progress on TCM treatment of CRA,the relationship between Wnt signaling pathway and CRA,and the related research on TCM prevention and treatment of CRA through Wnt signaling pathway.The aim is to provide strong evidence for the prevention and treatment of CRA and new strategies for TCM treatment of CRA.

关 键 词：结直肠腺瘤 WNT信号通路 中医药 防治 

分 类 号：R273[医药卫生—中西医结合]