夏苍和胃颗粒质量标准的研究  

Research on quality standard of Xiacang Hewei Granules

作　　者：张丽平 赵延强 崔正关 时振飞 赵兴奎 ZHANG Liping;ZHAO Yanqiang;CUI Zhengguan;SHI Zhenfei;ZHAO Xingkui(Department of Preparation,Heze Hospital of Traditional Chinese Medicine,Shandong,Heze 274000,China;Department of Rehabilitation,Heze Hospital of Traditional Chinese Medicine,Shandong,Heze 274000,China)

机构地区：[1]山东省菏泽市中医医院制剂室,山东菏泽274000 [2]山东省菏泽市中医医院康复科,山东菏泽274000

出　　处：《中国医药科学》2025年第7期69-73,共5页China Medicine And Pharmacy

基　　金：山东省重大科技创新工程“‘药+食’健康产业高质量发展科技示范工程”,山东省重点研发计划(科技示范工程)项目(2021SFGC1202)。

摘　　要：目的建立夏苍和胃颗粒的质量标准,有效控制该制剂的质量。方法采用薄层色谱法(TLC)对夏苍和胃颗粒中黄连、黄芩、甘草进行定性鉴别,采用高效液相色谱法(HPLC)对黄芩苷进行定量分析。结果夏苍和胃颗粒中黄连、黄芩、甘草的TLC鉴别均专属性强,斑点清晰,阴性无干扰。黄芩苷在6.44~128.8μg/ml范围内呈良好线性关系(r=0.9993),平均回收率为97.64%,RSD值为1.38%。结论该方法准确可靠,重复性好,专属性强,可用于夏苍和胃颗粒的质量控制。Objective To establish the quality standard of Xiacang Hewei Granules and effectively control the quality of this preparation.Methods Rhizoma Coptidis,Radix Scutellariae and Radix et Rhizoma Glycyrrhizae in Xiacang Hewei Granules were qualitatively identified by thin layer chromatography(TLC),and baicalin was quantitatively analyzed by high performance liquid chromatography(HPLC).Results The TLC identifications of Rhizoma Coptidis,Radix Scutellariae and Radix et Rhizoma Glycyrrhizae in Xiacang Hewei Granules were all highly specific,with clear spots and no negative interference.Baicalin showed a good linear relationship in the range of 6.44-128.8μg/ml(r=0.9993),with an average recovery of 97.64%and RSD of 1.38%.Conclusion The method is accurate,reliable,reproducible and specific,and can be used for the quality control of Xiacang Hewei Granules.

关 键 词：夏苍和胃颗粒 薄层色谱法 高效液相色谱法 黄芩苷 

分 类 号：R284.1[医药卫生—中药学] R927.2[医药卫生—中医学]