稽留流产患者维生素D水平及其与负性情绪和睡眠质量的相关性分析  

Analysis of the vitamin D level and its correlation with negative emotions and sleep quality in patients with missed abortion

作　　者：欧阳玲[1] 张婷 郑雯 夏建利 OUYANG Ling;ZHANG Ting;ZHENG Wen;XIA Jianli(Department of Obstetrics and Gynecology,Changsha Central Hospital Affiliated to Nanhua University,Hunan,Changsha 410004,China;School of Nursing,Changsha Health Vocational College,Hunan,Changsha 410600,China)

机构地区：[1]南华大学附属长沙中心医院妇产科,湖南长沙410004 [2]长沙卫生职业学院护理学院,湖南长沙410600

出　　处：《中国医药科学》2025年第7期148-151,175,共5页China Medicine And Pharmacy

基　　金：湖南省自然科学基金科卫联合项目(2021JJ70064);湖南省自然科学基金教科联合课题(2022JJ60112);湖南省医疗技术创新引导项目(2021SK53402);湖南省卫生健康委员会项目(D202314035974)。

摘　　要：目的探讨稽留流产(MA)患者血清维生素D(VitD)水平及其与负性情绪和睡眠质量的相关性。方法纳入2022年9月至2023年12月在长沙市中心医院妇产科门诊产检的323例MA患者为观察组,同期结局为正常足月妊娠的孕早期妇女796例为对照组,比较两组患者的血清25-羟维生素D[25(OH)D]水平、抑郁-焦虑-压力自评量表简体中文版(DASS-21)评分和匹兹堡睡眠质量指数量表(PSQI)评分。血清25(OH)D<50 nmol/L判定为VitD缺乏,比较不同VitD水平MA患者的DASS-21和PSQI评分,采用Spearman相关分析25(OH)D水平与PSQI的相关性。结果MA患者的血清25(OH)D水平低于对照组,DASS-21和PSQI评分高于对照组,差异有统计学意义(P<0.05)。MA患者中VitD缺乏组和VitD正常组的DASS-21评分比较,差异无统计学意义(P>0.05);VitD缺乏组的PSQI评分高于VitD正常组,差异有统计学意义(P<0.05)。Spearman相关分析结果显示,VitD水平与MA患者的PSQI评分呈负相关(r=-0.260,P<0.001)。结论MA患者的血清VitD水平和睡眠质量低于正常孕早期孕妇,负性情绪高于正常孕早期孕妇。VitD缺乏与MA患者的睡眠质量密切相关,与负性情绪是否相关尚缺乏相关证据。Objective To investigate the serum vitamin D(VitD)level and its correlation with negative emotions and sleep quality in patients with missed abortion(MA).Methods A total of 323 patients with MA who underwent outpatient obstetric examinations at the Department of Obstetrics and Gynecology of Changsha Central Hospital from September 2022 to December 2023 were included as the observation group.796 women in early pregnancy with normal full-term pregnancy outcomes during the same period were included as the control group.The serum 25-hydroxyvitamin D(25[OH]D)level,the score of the short-form version of the depression anxiety stress scales(DASS-21),and the score of Pittsburgh sleep quality index(PSQI)scale of patients were compared between the two groups.A serum 25(OH)D level of<50 nmol/L was determined to indicate VitD deficiency.The DASS-21 score and PSQI score of MA patients with different VitD levels were compared.The correlation between 25(OH)D levels and PSQI was analyzed using the Spearman correlation analysis.Results The serum 25(OH)D level was lower,and DASS-21 score and PSQI score were higher in patients with MA than those in the control group,with statistically significant differences(P<0.05).Comparison of the DASS-21 score between the VitD-deficient group and the VitDnormal group of patients with MA showed no statistically significant difference(P>0.05).The PSQI score was higher in the VitD-deficient group than in the VitD-normal group,with a statistically significant difference(P<0.05).Spearman correlation analysis indicated that the VitD level was negatively correlated with the PSQI score in patients with MA(r=-0.260,P<0.001).Conclusion The serum VitD level and sleep quality are lower,and the experience of negative emotions is higher in patients with MA than in normal pregnant women in early pregnancy.VitD deficiency is strongly associated with sleep quality in patients with MA,although evidence regarding its relationship with negative emotions is lacking.

关 键 词：维生素D 稽留流产 负性情绪 睡眠质量 

分 类 号：R714.21[医药卫生—妇产科学]