基于文献挖掘的慢性盆腔炎动物模型应用分析  

Application Analysis of Chronic Pelvic Inflammatory Disease Animal Model Based on Literature Mining

作　　者：李苒 杨凤娟 喻志丽 轩婉璐 李至慧 介嘉悦 张晓静 何群力 LI Ran;YANG Fengjuan;YU Zhili;XUAN Wanlu;LI Zhihui;JIE Jiayue;ZHANG Xiaojing;HE Qunli(Basic Medicine Department of Zhengzhou Medical and Health Vocational College,Xinmi 450046,Henan,China)

机构地区：[1]郑州医药健康职业学院基础医学部,河南新密450046

出　　处：《医学信息》2025年第9期42-49,共8页Journal of Medical Information

摘　　要：目的通过研究慢性盆腔炎动物模型造模方法及各项检查指标要素,为提高其造模的成功率、评价受试药物有效性提供方法学参考。方法以“慢性盆腔炎”和“动物模型”为主题词,搜索中国知网(CNKI)、万方数据库(Wanfang)、PubMed和Web of Science(WoS)等数据库,收集实验动物种类、造模方法、造模时长、给药周期、检测指标等建立数据库并进行处理,归纳常用造模方法、造模关键因素及模型特点等。结果纳入符合标准的文献133篇,其中使用最多的实验动物种类为180~240 g雌性SD大鼠;使用最多的造模方法为双侧子宫内注射25%苯酚胶浆法;混合菌液感染法和化学灼烧法造模时间均以7 d居多,混合菌液感染法给药周期以21 d居多,化学灼烧法给药周期以14 d居多,异物置入法造模时间为14 d,给药周期为21 d;高频检测指标为HE染色观察子宫组织病理和血清TNF-α、IL-6、IL-1β水平等,聚类可分为8类。结论现有慢性盆腔炎动物模型多为单因素模型,模型检测指标与中医症候结合度较低,应建立较为全面的CPID中西医病症结合模型,利于后续药效或机制等研究的科学开展。Objective To provide a methodological reference for improving the success rate of modeling and evaluating the effectiveness of the tested drugs by studying the modeling method and various examination index elements of animal models of chronic pelvic inflammatory disease.Methods With“chronic pelvic inflammatory disease”and“animal model”as the key words,databases such as CNKI,Wanfang,Pubmed and Web of Science(WoS)were searched.The types of experimental animals,modeling methods,modeling time,administration period,and detection indicators were collected to establish and process the database,and the commonly used modeling methods,key factors for modeling,and model characteristics were summarized.Results A total of 133 articles were included,of which 180-240 g female SD rats were the most widely used experimental animals.The most commonly used modeling method was bilateral intrauterine injection of 25%phenol mucilage.The modeling time of mixed bacterial infection method and chemical burning method was mostly 7 days,the administration cycle of mixed bacterial infection method was mostly 21 days,the administration cycle of chemical burning method was mostly 14 days,the modeling time of foreign body placement method was 14 days,and the administration cycle was 21 days.The high-frequency detection indexes were HE staining to observe uterine tissue pathology and serum TNF-α,IL-6,IL-1βlevels,etc.,and the clustering could be divided into 8 categories.Conclusion The existing animal models of chronic pelvic inflammatory disease are mostly single-factor models,and the combination of model detection indicators and TCM symptoms is low.A more comprehensive CPID model of integrated traditional Chinese and Western medicine should be established,which is conducive to the scientific development of subsequent research on efficacy or mechanism.

关 键 词：慢性盆腔炎 动物模型 数据挖掘 应用分析 生化指标 

分 类 号：R271.1[医药卫生—中医妇科学]