沙库巴曲缬沙坦联合八段锦对心力衰竭合并室性心律失常的临床疗效研究  

Study on the Clinical Effect of Sacubitril/Valsartan Combined with Baduanjin on Heart Failure Complicated with Ventricular Arrhythmia

作　　者：刘文烜 胡晋 钟小丽 周盛辉 LIU Wenxuan;HU Jin;ZHONG Xiaoli;ZHOU Shenghui(Department of Emergency,Shangyou County Hospital of Traditional Chinese Medicine,Shangyou 341200,Jiangxi,China)

机构地区：[1]上犹县中医院急诊科,江西上犹341200

出　　处：《医学信息》2025年第9期105-109,共5页Journal of Medical Information

基　　金：江西省中医药管理局科技计划项目(编号:2023B1044)。

摘　　要：目的研究沙库巴曲缬沙坦联合八段锦对心力衰竭合并室性心律失常的临床疗效。方法选取上犹县中医院2023年1月-10月收治的60例心力衰竭合并室性心律失常患者为研究对象,按照随机数字表法将其分为对照组和研究组,每组30例。对照组口服沙库巴曲缬沙坦钠片治疗,研究组在对照组的基础上增加中医传统功法八段锦治疗。比较两组心功能[左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)、射血分数(EF)]、脑利钠肽前体(Pro-Bnp)、血清C反应蛋白(CRP)水平、校正QT间期离散度(QTcd)变化、6 min步行试验(6MWT)水平、临床疗效、不良事件(恶心呕吐、腹痛、肝肾心血管功能异常)发生率。结果研究组治疗后EF值高于对照组,LVESd、LVEEd水平均低于对照组(P<0.05)。研究组Pro-Bnp、CRP水平低于对照组(P<0.05)。研究组QTcd水平低于对照组(P<0.05)。研究组6MWT长于对照组(P<0.05)。研究组治疗总有效率高于对照组(P<0.05)。研究组不良事件发生率低于对照组(P<0.05)。结论沙库巴曲缬沙坦联合八段锦治疗心力衰竭合并室性心律失常的临床疗效确切,能够提高患者心功能和运动能力,降低炎症因子水平和QTcd水平,减少不良事件的发生,值得临床应用。Objective To study the clinical effect of sacubitril/valsartan combined with Baduanjin on heart failure complicated with ventricular arrhythmia.Methods A total of 60 patients with heart failure complicated with ventricular arrhythmia admitted to Shangyou County Hospital of Traditional Chinese Medicine from January to October 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 30 patients in each group.The control group was treated with sacubitril/valsartan sodium tablets orally,and the study group was treated with traditional Chinese medicine Baduanjin on the basis of the control group.The cardiac function[left ventricular end-diastolic diameter(LVEDd),left ventricular end-systolic diameter(LVESd),ejection fraction(EF)],brain natriuretic peptide precursor(Pro-Bnp),serum C-reactive protein(CRP)levels,corrected QT interval dispersion(QTcd)changes,six-minute walking test(6MWT)levels,clinical efficacy,and incidence of adverse events(nausea and vomiting,abdominal pain,liver and kidney cardiovascular dysfunction)were compared between the two groups.Results After treatment,the EF value of the study group was higher than that of the control group,and the levels of LVESD and LVEED were lower than those of the control group(P<0.05).The levels of Pro-Bnp and CRP in the study group were lower than those in the control group(P<0.05).The QTcd level of the study group was lower than that of the control group(P<0.05).The 6MWT of the study group was longer than that of the control group(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).The incidence of adverse events in the study group was lower than that in the control group(P<0.05).Conclusion Sacubitril/valsartan combined with Baduanjin has a definite clinical effect in the treatment of heart failure complicated with ventricular arrhythmia,which can improve the cardiac function and exercise capacity of patients,reduce the

关 键 词：沙库巴曲缬沙坦 八段锦 心力衰竭 室性心律失常 

分 类 号：R541.7[医药卫生—心血管疾病] R541.6[医药卫生—内科学]