硝苯地平治疗妊娠高血压综合征的效果及对妊娠结局的影响  

Effect of Nifedipine in the Treatment of Pregnancy-induced Hypertension Syndrome and its Effect on Pregnancy Outcome

作　　者：夏水珍 XIA Shuizhen(Obstetrics and Gynecology Department of Xinjian District People′s Hospital,Nanchang 330100,Jiangxi,China)

机构地区：[1]新建区人民医院妇产科,江西南昌330100

出　　处：《医学信息》2025年第9期125-128,共4页Journal of Medical Information

摘　　要：目的分析硝苯地平治疗妊娠高血压综合征(PIH)的临床效果。方法纳入新建区人民医院于2022年1月-2023年12月收治的76例PIH患者,行随机数字表法分为观察组(38例)与对照组(38例),对照组给予硫酸镁治疗,观察组在其基础上联合硝苯地平治疗,比较两组用药效果、血压指标[收缩压(SBP)、舒张压(DBP)]、症状体征(尿蛋白含量、水肿评分)、药物不良反应、妊娠结局。结果观察组治疗有效率高于对照组(P<0.05)。两组治疗后SBP、DBP指标低于治疗前,且观察组SBP、DBP指标低于对照组(P<0.05)。两组治疗后尿蛋白含量、水肿评分均低于治疗前,且观察组尿蛋白含量、水肿评分低于对照组(P<0.05)。两组药物不良反应对比,差异无统计学意义(P>0.05)。观察组不良妊娠结局发生率低于对照组(P<0.05)。结论硝苯地平治疗PIH效果确切,可缓解患者血压水平及临床症状,降低其不良妊娠结局风险,安全性较高。Objective To analyze the clinical efficacy of nifedipine in the treatment of pregnancy-induced hypertension(PIH).Methods A total of 76 patients with PIH admitted to the Xinjian District People's Hospital from January 2022 to December 2023 were randomly divided into observation group(38 patients)and control group(38 patients).The control group was treated with magnesium sulfate,and the observation group was treated with nifedipine on the basis of magnesium sulfate.The medication effect,blood pressure index[systolic blood pressure(SBP),diastolic blood pressure(DBP)],symptoms and signs(urinary protein content,edema score),adverse drug reactions and pregnancy outcome were compared between the two groups.Results The treatment efficacy in the observation group was significantly higher than that in the control group(P<0.05).After treatment,both the SBP and DBP of the two groups were lower than those before treatment,moreover,the SBP and DBP of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the urine protein content and edema scores of both groups decreased than those before treatment,and those of the observation group were significantly lower than those of the control group(P<0.05).The incidence of adverse drug reactions was no significant difference between the two groups(P>0.05).The incidence of adverse pregnancy outcomes in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Nifedipine is effective in the treatment of PIH,which can alleviate the blood pressure level and clinical symptoms of patients,reduce the risk of adverse pregnancy outcomes,and has high safety.

关 键 词：妊娠高血压综合征 硝苯地平 妊娠结局 尿蛋白 水肿 药物不良反应 

分 类 号：R714.246[医药卫生—妇产科学]