阿卡波糖联合甘精胰岛素、甲巯咪唑治疗2型糖尿病合并甲状腺功能亢进症的临床效果观察  

Observation on Clinical Effect of Acarbose Combined with Insulin Glargine and Thiamazole in Treatment of Type 2 Diabetes Mellitus Complicated with Hyperthyroidism

作　　者：宋长虹[1] Song Changhong(Department of Endocrinology,Feixian People's Hospital,Linyi 273400,Shandong Province,China)

机构地区：[1]费县人民医院内分泌科,山东临沂273400

出　　处：《中国社区医师》2025年第9期15-17,共3页Chinese Community Doctors

摘　　要：目的:探讨阿卡波糖联合甘精胰岛素、甲巯咪唑治疗2型糖尿病合并甲状腺功能亢进症的临床效果。方法:将2021年1月—2022年12月费县人民医院内分泌科收治的74例2型糖尿病合并甲状腺功能亢进症患者随机分为两组,各37例。两组均使用甲巯咪唑治疗,在此基础上,对照组使用阿卡波糖治疗,观察组使用阿卡波糖联合甘精胰岛素治疗。对比两组临床疗效。结果:治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素水平降低,且观察组低于对照组(P<0.05)。治疗后,两组三碘甲状腺原氨酸、四碘甲腺原氨酸、游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺激素水平降低,且观察组低于对照组(P<0.05)。观察组血糖达标时间、住院时间短于对照组(P<0.05)。观察组治疗总有效率为94.59%,高于对照组(P<0.05)。结论:阿卡波糖联合甘精胰岛素、甲巯咪唑治疗2型糖尿病合并甲状腺功能亢进症的临床效果显著,能改善患者血糖水平、胰岛功能与甲状腺功能,促进患者康复。Objective:To investigate the clinical effect of acarbose combined with insulin glargine and thiamazole in treatment of type 2 diabetes mellitus complicated with hyperthyroidism.Methods:A total of 74 patients with type 2 diabetes mellitus complicated with hyperthyroidism admitted to the Department of Endocrinology of Feixian People's Hospital from January 2021 to December 2022 were randomly divided into two groups,with 37 cases in each group.Both groups were treated with thiamazole.On this basis,the control group was treated with acarbose,and the observation group was treated with acarbose combined with insulin glargine.The clinical efficacy of the two groups was compared.Results:After treatment,the levels of fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin and fasting insulin in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of triiodothyronine,tetraiodothyronine,free triiodothyronine,free thyroxine and thyroid-stimulating hormone in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05).The time of blood glucose attainment and the length of hospital stay in the observation group were shorter than those in the control group(P<0.05).The total effective rate of treatment in the observation group was 94.59%,which was higher than that in the control group(P<0.05).Conclusion:Acarbose combined with insulin glargine and thiamazole has significant clinical effect in the treatment of type 2 diabetes mellitus complicated with hyperthyroidism,and can improve blood glucose level,pancreatic islet function and thyroid function of patients,and promote the recovery of patients.

关 键 词：2型糖尿病 甲状腺功能亢进症 阿卡波糖 甘精胰岛素 甲巯咪唑 

分 类 号：R581.1[医药卫生—内分泌] R587.1[医药卫生—内科学]