Nesfatin-1对卵巢功能影响的研究进展  

Advancements in research on the influence of Nesfatin-1 on ovarian function

作　　者：李睿 姚景芳 钟丽蓉 李清春[1] LI Rui;YAO Jingfang;ZHONG Lirong;LI Qingchun(Department of Reproductive Medicine,Binzhou Medical University Hospital,Shandong Province,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院生殖医学科,山东滨州256600

出　　处：《妇儿健康导刊》2025年第8期32-35,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：Nesfatin-1是由Nucleobindin-2前体蛋白经特定酶切反应生成的多肽,最初在下丘脑中被发现,以显著的食欲抑制功能而备受关注。近年来,更多的研究表明,Nesfatin-1不仅在能量代谢中发挥重要作用,还在多种生理过程中,尤其是生殖系统的调控中扮演关键角色。Nesfatin-1通过对抗卵巢氧化应激及凋亡损伤,调节生殖激素分泌,保护卵巢健康,进而改善卵巢功能。本文主要阐述Nesfatin-1对卵巢功能影响方面的研究进展。Nesfatin-1 is a peptide derived from the enzymatic cleavage of the Nucleobindin-2 precursor protein.Nesfatin-1 is initially discovered in the hypothalamus,notable for its appetite-suppressing function.Recent studies have further elucidated its role in energy metabolism and its critical involvement in various physiological processes,particularly in the regulation of the reproductive system.Nesfatin-1 protects ovarian health by combating oxidative stress and apoptosis,and regulating reproductive hormone secretion,thereby improving ovarian function.This article primarily addresses the recent research advancements concerning the influence of Nesfatin-1 on ovarian function.

关 键 词：NESFATIN-1 氧化应激 能量代谢 多囊卵巢综合征 辅助生殖技术 

分 类 号：R711[医药卫生—妇产科学]