阴道用乳杆菌活菌胶囊辅助人干扰素α2b凝胶对宫颈高危型人乳头瘤病毒感染患者病毒转阴及阴道微生态的影响  

Effect of Live Lactobacillus Capsule for Vaginal Use assisted Human Interferonα2b Gel on virus negative transformation and vaginal microe-cology in patients with cervical high risk human papilloma virus infection

作　　者：魏淑霞 WEI Shuxia(Department of Obstetrics and Gynecology,Binzhou Bincheng District Municipal Hospital,Shandong Province,Binzhou 256600,China)

机构地区：[1]山东省滨州市滨城区市立医院妇产科,山东滨州256600

出　　处：《妇儿健康导刊》2025年第8期36-39,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨阴道用乳杆菌活菌胶囊辅助人干扰素α2b凝胶对宫颈高危型人乳头瘤病毒(HPV)感染患者病毒转阴及阴道微生态的影响。方法选取滨州市滨城区市立医院2022年1月至2023年10月收治的宫颈高危型HPV感染患者194例,按照随机数字表法分为对照组(97例)和观察组(97例)。对照组给予人干扰素α2b凝胶治疗,观察组加用阴道用乳杆菌活菌胶囊治疗,对比两组治疗总有效率、阴道微生态指标、不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。观察组菌群密集度Ⅱ~Ⅲ级、菌群多样性Ⅱ~Ⅲ级、乳杆菌、阴道pH值3.8~4.5、过氧化氢阴性、唾液酸酶阴性、白细胞酯酶阴性占比高于对照组(P<0.05)。两组不良反应总发生率比较无差异(P>0.05)。结论阴道用乳杆菌活菌胶囊辅助人干扰素α2b凝胶治疗宫颈高危型HPV感染患者,能促进HPV转阴,调节阴道微生态。Objective To explore the effect of Live Lactobacillus Capsule for Vaginal Use assisted Human Interferonα2b Gel on virus negative transformation and vaginal microecology in patients with cervical high risk human papilloma virus(HPV)infection.Methods A total of 194 patients with cervical high risk HPV infection admitted to Binzhou Bincheng District Municipal Hospital from January 2022 to October 2023 were selected and divided into control group(97 cases)and observation group(97 cases)according to the random number table method.The control group was treated with Human Interferonα2b,and the observation group was treated with Live Lactobacillus Capsule for Vaginal Use.The total effective rate,vaginal microecological indicators,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The proportions ofⅡ-Ⅲgrade of flora density,Ⅱ-Ⅲgrade of flora diversity,Lactobacillus,vaginal pH value 3.8-4.5,negative hydrogen peroxide,negative sialidase,and negative leukocyte esterase in the observation group were higher than those in the control group(P<0.05).There was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Live Lactobacillus Capsule for Vaginal Use assisted Human Interferonα2b Gel in the treatment of patients with cervical high risk HPV infection can promote HPV turn negative and regulate the vaginal microecological.

关 键 词：高危型人乳头瘤病毒感染 阴道用乳杆菌活菌胶囊 人干扰素α2b凝胶 阴道微生态 

分 类 号：R711[医药卫生—妇产科学]