乙酰半胱氨酸雾化联合门冬氨酸阿奇霉素对肺炎支原体肺炎患儿免疫功能及炎症反应的影响  

Impact of Acetylcysteine atomization combined with Azithromycin Aspar-tate on immune function and inflammatory reaction in children with Mycoplasma pneumoniae pneumonia

作　　者：宋文秀 SONG Wenxiu(Shanxian Dongda Hospital,Shandong Province,Shanxian 274300,China)

机构地区：[1]山东省单县东大医院,山东单县274300

出　　处：《妇儿健康导刊》2025年第8期111-114,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨乙酰半胱氨酸雾化联合门冬氨酸阿奇霉素对肺炎支原体肺炎患儿免疫功能及炎症反应的影响。方法选取2021年9月至2024年6月单县东大医院收治的130例肺炎支原体肺炎患儿,采用随机数字表法分为对照组与观察组,各65例。对照组采用门冬氨酸阿奇霉素治疗,观察组在对照组基础上加用乙酰半胱氨酸雾化治疗。比较两组症状改善情况、住院时间、免疫功能、炎症反应、不良反应。结果观察组各项症状改善时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组免疫球蛋白A、免疫球蛋白M、免疫球蛋白G水平均高于对照组,白细胞介素-6、白细胞介素-4、肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论乙酰半胱氨酸雾化联合门冬氨酸阿奇霉素治疗肺炎支原体肺炎患儿的临床效果显著,可促进症状改善,减轻炎症反应,提高免疫功能。Objective To investigate the impact of Acetylcys teine atomization combined with Azithrom ycin Aspartate on immune function and inflammatory reaction in children with Mycoplasma pneumoniae pneumonia.Methods From September 2021 to June 2024,130 children with Mycoplasma pneumoniae pneumonia admitted to Shanxian Dongda Hospital were selected and divided into the control group and the observation group using the random number table method,with 65 cases in each group.The control group was treated with Azithromycin Aspartate,and the observation group was treated with Acetylcysteine atomization on the basis of the control group.The improvement of symptoms,hospitalization time,immune function,inflammatory reaction,and adverse reactions were compared between the two groups.Results The improvement time of symptoms and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of immunoglobulin A,immunoglobulin M,and immunoglobulin G in the observation group were higher than those in the control group,and the levels of interleukin-6,interleukin-4,and tumor necrosis factor-αin the observation group were lower than those in the control group,with statistical differences(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Acetylcysteine atomization combined with Azithromycin Aspartate in the treatment of children with Mycoplasma pneumoniae pneumonia is significant,which can promote the improvement of symptoms,reduce inflammatory reaction,and improve immune function.

关 键 词：乙酰半胱氨酸 雾化吸入 门冬氨酸阿奇霉素 肺炎支原体肺炎患儿 炎症反应 免疫功能 

分 类 号：R725.6[医药卫生—儿科]