鲁南地区不同孕期甲状腺功能指标参考区间的建立  

Establishment of reference intervals of thyroid function indexes in different pregnancy periods in Lunan region

作　　者：刘婷[1] 高晓梅[1] 姜家利[1] 孙阳[1] 刘爱香[1] LIU Ting;GAO Xiaomei;JIANG Jiali;SUN Yang;LIU Aixiang(Zaozhuang Municipal Hospital,Zaozhuang 277102,China)

机构地区：[1]枣庄市立医院,山东枣庄277102

出　　处：《临床医学研究与实践》2025年第12期1-4,共4页Clinical Research and Practice

基　　金：国家重点研发计划-“基础科研条件与重大科学仪器设备研发”重点专项项目(No.2022YFF0710300)。

摘　　要：目的建立鲁南地区妊娠妇女不同孕期甲状腺功能指标参考区间,为本地区妊娠妇女甲状腺疾病的准确诊断提供参考依据。方法选取399名妊娠妇女作为妊娠组,根据不同孕期将其分为妊娠早期(T1组,133名)、妊娠中期(T2组,133名)、妊娠晚期(T3组,133名);另选取同期健康非妊娠妇女200名作为对照组(T0组)。检测所有研究对象的游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-Ab)及甲状腺球蛋白抗体(Tg-Ab)水平。比较妊娠妇女不同孕期甲状腺功能指标水平;建立妊娠妇女不同孕期甲状腺功能指标参考区间;比较不同参考区间诊断妊娠甲状腺功能异常的检出率。结果T1组、T2组、T3组及T0组的FT_(3)、FT_(4)、TSH水平比较,差异具有统计学意义(P<0.05)。妊娠妇女中,T1组的FT_(3)、FT_(4)水平最高,TSH水平最低,随着孕周增加,FT_(3)、FT_(4)水平逐渐降低,TSH水平逐渐升高。T1组、T2组、T3组的FT_(3)参考区间分别为2.50~3.90 pg/mL、2.17~3.54 pg/mL、2.24~3.27 pg/mL,FT_(4)参考区间分别为0.91~1.71 ng/dL、0.86~1.38 ng/dL、0.75~1.26 ng/dL,TSH参考区间分别为0.06~5.12μIU/mL、0.39~4.32μIU/mL、0.43~4.13μIU/mL。根据指南参考区间对妊娠期甲状腺功能异常的检出率低于本地区建立的参考区间(P<0.05)。结论建立鲁南地区不同孕期甲状腺功能指标参考区间,不仅能够揭示妊娠妇女不同孕期甲状腺激素变化规律,还可提升甲状腺疾病检出率。Objective To establish the reference intervals of thyroid function indexes of pregnant women in different pregnancy periods in Lunan region,and to provide reference for the accurate diagnosis of thyroid diseases in pregnant women in this region.Methods A total of 399 pregnant women were selected as pregnancy group,according to different pregnancy periods,the pregnant women were divided into early pregnancy group(T1 group,133 people),middle pregnancy group(T2 group,133 people)and late pregnancy group(T3 group,133 people);another 200 healthy non-pregnant women in the same period were selected as control group(T0 group).The levels of free triiodothyronine(FT_(3)),free thyroxine hormone(FT_(4)),thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPO-Ab)and thyroglobulin antibody(Tg-Ab)were detected in all research objects.The levels of thyroid function indexes in pregnant women during different pregnancy periods were compared;the reference intervals of thyroid function indexes of pregnant women in different pregnancy periods were established;the detection rates of thyroid dysfunction in pregnancy periods diagnosed by different reference intervals were compared.Results There were statistically significant differences the levels of FT_(3),FT_(4) and TSH between the T1 group,the T2 group,the T3 group and the T0 group(P<0.05).The levels of FT_(3) and FT_(4) in the T1 group of pregnant women were the highest,the level of TSH was the lowest,with the increase of gestational age,the levels of FT_(3) and FT_(4) gradually decreased,and TSH level gradually increased.The reference intervals of FT_(3) in the T1 group,the T2 group and the T3 group were 2.50-3.90 pg/mL,2.17-3.54 pg/mL and 2.24-3.27 pg/mL,respectively,the reference intervals of FT_(4) were 0.91-1.71 ng/dL,0.86-1.38 ng/dL and 0.75-1.26 ng/dL,respectively,the reference intervals of TSH were 0.06-5.12μIU/mL,0.39-4.32μIU/mL and 0.43-4.13μIU/mL,respectively.The detection rate of thyroid dysfunction in pregnancy periods by reference interval of the guidelines

关 键 词：鲁南地区 不同孕期 游离三碘甲状腺原氨酸 游离甲状腺素 促甲状腺激素 

分 类 号：R71[医药卫生—妇产科学]