基于网络药理学探讨蛇床子治疗银屑病的机制研究  

Study on the mechanism of Cnidii fructus in the treatment of psoriasis based on network pharmacology

作　　者：沈正元 文昌晖 张仲昭 SHEN Zhengyuan;WEN Changhui;ZHANG Zhongzhao(Guizhou University of Traditional Chinese Medicine,Guiyang 550025;the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州中医药大学第一附属医院,贵州贵阳550001

出　　处：《临床医学研究与实践》2025年第12期5-8,共4页Clinical Research and Practice

基　　金：贵州省中医药管理局中医药、民族医药科学技术研究课题(No.QZYY-2024-020);贵州省中医药管理局-国家中医优势专科项目(黔中医药函〔2023〕2号);贵州中医药大学皮肤病研究中心项目(贵中医科发〔2021〕12号)。

摘　　要：目的利用网络药理学方法探讨蛇床子治疗银屑病(PSO)的机制,为其临床运用提供理论依据。方法在SymMap v2数据库与中药系统药理学数据库分析平台(TCMSP)筛选蛇床子的主要活性成分与对应的靶点,在GeneCards疾病数据库中筛选PSO的疾病相关靶点。利用Venny2.1.0在线网站获取蛇床子-PSO共靶点,利用STRING数据库处理上述交集靶点,获得蛋白互作(PPI)关系数据,经Cytoscape3.8.0软件处理后,根据Degree值选出蛇床子治疗PSO的核心靶点。最后在DAVID数据库中进行KEGG信号通路富集分析和GO功能富集分析,富集结果用微生信网站制图展示。结果蛇床子治疗PSO的核心靶点为白蛋白(ALB)、胰岛素(INS)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、RAC-α丝氨酸/苏氨酸蛋白激酶(AKT1)。蛇床子主要通过PI3K/AKT等信号通路治疗PSO。结论蛇床子通过中药多靶点、多条信号通路发挥治疗PSO的作用。Objective To explore the mechanism of Cnidii fructus in the treatment of psoriasis(PSO)by using network pharmacology method,and to provide theoretical basis for its clinical application.Methods The main active components and corresponding targets of Cnidii fructus were screened in SymMap v2 database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the disease-related targets of PSO were screened in GeneCards disease database.The Venny2.1.0 online website was used to obtain the common target of Cnidii fructus-PSO,and the STRING database was used to process the above intersection targets to obtain the protein-protein interaction(PPI)relationship data.After processing by Cytoscape3.8.0 software,the core target of Cnidii fructus in the treatment of PSO was selected according to the Degree value.Finally,KEGG signal pathway enrichment analysis and GO function enrichment analysis were performed in the DAVID database,and the enrichment results were displayed on the WeChat website.Results The core targets of Cnidii fructus in the treatment of PSO are albumin(ALB),insulin(INS),interleukin-6(IL-6),tumor necrosis factor(TNF),RAC-αserine/threonine protein kinase(AKT1).Cnidii fructus mainly treats PSO through signaling pathways such as PI3K/AKT.Conclusion Cnidii fructus plays a role in the treatment of PSO through multiple targets and multiple signaling pathways of traditional Chinese medicine.

关 键 词：银屑病 蛇床子 网络药理学 

分 类 号：R275.9[医药卫生—中西医结合]