猪流行性腹泻病毒的肠道致病机制及营养调控研究进展  

Research Progress on Intestinal Pathogenesis and Nutritional Regulation of Porcine Epidemic Diarrhea Virus

作　　者：杨杰波 严鸿林 伍爱民 张勇 YANG Jiebo;YAN Honglin;WU Aimin;ZHANG Yong(College of Life Science and Engineering,Southwest University of Science and Technology,Mianyang 621010,China;Key Laboratory of Animal Disease-Resistance Nutrition of Ministry of Education,Institute of Animal Nutrition,Sichuan Agricultural University,Chengdu 611130,China)

机构地区：[1]西南科技大学生命科学与工程学院,绵阳621010 [2]四川农业大学动物营养研究所,动物抗病营养教育部重点实验室,成都611130

出　　处：《动物营养学报》2025年第4期2142-2156,共15页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：四川省自然科学基金面上项目(2024NSFSC0297)。

摘　　要：猪流行性腹泻病毒(PEDV)是一种具有高度传染性的肠道冠状病毒,可导致新生仔猪出现萎缩性肠炎、水样腹泻和脱水,是造成新生仔猪死亡的主要病原。营养物质的供给是维持动物生长和健康所必需的,也可直接或间接作用于病毒,抑制PEDV的复制和活性,并通过增强仔猪的免疫性能、抗氧化和抗炎能力来修复PEDV感染所引起的肠道损伤,从而维持仔猪的肠道健康。营养物质在缓解PEDV对仔猪的影响中主要通过增强仔猪的免疫力和抑制PEDV活性来发挥抗PEDV作用。本文在综述PEDV肠致病机制的基础上,重点介绍了PEDV对仔猪的影响和缓解PEDV的营养调控作用研究进展,以期为深入研究营养调控对PEDV的作用机制和开发抗病毒营养调控技术提供理论参考。Porcine epidemic diarrhea virus(PEDV)is a highly infectious enteric coronavirus,which can cause atrophic enteritis,watery diarrhea and dehydration in newborn piglets,and is the main cause of death in newborn piglets.The provision of nutrients is essential for sustaining animal growth and health,while also exerting direct or indirect effects on the virus by inhibiting PEDV replication and activity,as well as repairing intestinal damage caused by PEDV infection through enhancing piglet immune performance,antioxidant capacity,and anti-inflammatory ability to maintain intestinal health.Nutrients play an anti-PEDV role in alleviating the effects of PEDV on piglets mainly by enhancing immunity and inhibiting PEDV activity of piglets.Therefore,based on a review of the pathogenesis of PEDV in the intestine,this paper focuses on the research progress on the effects of PEDV on piglets and the nutritional regulation in alleviating PEDV,aiming to provide theoretical reference for further study of the mechanism of nutrition regulation on PEDV and development of antiviral nutrition regulation technology.

关 键 词：猪流行性腹泻病毒 致病机制 仔猪 肠道健康 营养调控 

分 类 号：S853[农业科学—临床兽医学]