色氨酸代谢与肠道微生物互作调控肠道健康的机制研究进展  

Advances in Research on Mechanism of Tryptophan Metabolism-Intestinal Microbes Interaction in Regulating Intestinal Health

作　　者：刘宇炎 李铁军[2] 印遇龙[2] 何流琴 LIU Yuyan;LI Tiejun;YIN Yulong;HE Liuqin(Hunan Province Key Laboratory of Animal Intestinal Function and Regulation,College of Life Sciences,Hunan Normal University,Changsha 410081,China;Key Laboratory of Animal Nutritional Physiology and Metabolic Processes of Hunan Province,National Engineering Laboratory of Pollution Control and Resource Technology for Livestock and Poultry Breeding,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China)

机构地区：[1]湖南师范大学生命科学学院,动物肠道功能与调控湖南省重点实验室,长沙410081 [2]中国科学院亚热带农业生态研究所,畜禽养殖污染控制与资源化技术国家工程实验室,动物营养生理与代谢过程湖南省重点实验室,长沙410125

出　　处：《动物营养学报》2025年第4期2157-2167,共11页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(U23A20233,32172755,32130099);湖南省科技创新“领军人才”项目(2023RC1054);湖南省重点研发项目(2022NK2023);湖南省重大基础研究项目(2024JC0007)。

摘　　要：色氨酸作为一种必需氨基酸,可以通过肠道微生物群和组织细胞中的多种代谢途径转化成具有不同生物活性的代谢产物,包括吲哚衍生物、5-羟色胺和犬尿氨酸等。研究表明,色氨酸及其代谢产物在维持肠道微生态平衡、调节宿主免疫应答和肠道屏障功能等方面发挥着关键作用,而肠道微生物代谢产生的色氨酸及其代谢产物,也可作为细胞间重要信号分子与宿主肠道上皮细胞进行相互调节,进而影响肠道健康。因此,本文围绕色氨酸代谢-肠道微生物的关系,重点综述了色氨酸代谢-肠道微生物之间的互作和调控肠道健康的分子机制以及其在肠道相关疾病中的潜在作用,以期为肠道微生物和色氨酸及其代谢物预防和治疗胃肠道疾病提供参考。Tryptophan,as an essential amino acid,can be converted into various biologically active metabolites through diverse metabolic pathways within the intestinal microbiota and tissue cells,including indole derivatives,serotonin,and kynurenine.Studies have demonstrated that tryptophan and these metabolites play crucial roles in maintaining intestinal microbiota balance,regulating host immune responses,and enhancing intestinal barrier function.Additionally,tryptophan and its metabolites produced by the metabolism of intestinal microbiota can act as essential intercellular signaling molecules,interacting with host intestinal epithelial cells to regulate and influence gut health.Therefore,this article centers on the relationship between tryptophan metabolism and intestinal microbiota,delving into the molecular mechanisms of tryptophan metabolism-intestinal microbes interaction in regulating intestinal health and its potential role in gut-related diseases.The ultimate goal is to provide novel insights and methodologies for the prevention and treatment of gastrointestinal disorders utilizing intestinal microbiota,tryptophan,and its metabolites.

关 键 词：色氨酸代谢 肠道健康 微生物 免疫 

分 类 号：S811.2[农业科学—畜牧学]