肠道损伤对断奶仔猪生长性能、血清和空肠炎症因子影响的Meta分析  

A Meta-Analysis of Effects of Intestinal Injury on Growth Performance,Serum and Jejunal Inflammatory Factors in Weaned Piglets

作　　者：陈少珍 高靖春 姚康 蒋宗勇 曹舒婷 王丽 CHEN Shaozhen;GAO Jingchun;YAO Kang;JIANG Zongyong;CAO Shuting;WANG Li(College of Animal Science,South China Agricultural University,Guangzhou 510642,China;Guangdong Provincial Key Laboratory of Livestock and Poultry Breeding and Nutrition,State Key Laboratory of Swine and Poultry Breeding Industry,Key Laboratory of Animal Nutrition and Feed in South China,Ministry of Agriculture and Rural Affairs,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;College of Animal Science and Technology,Southwest University,Chongqing 400700,China)

机构地区：[1]华南农业大学动物科学学院,广州510642 [2]广东省农业科学院动物科学研究所,农业农村部华南动物营养与饲料重点实验室,猪禽种业全国重点实验室,广东省畜禽育种与营养重点实验室,广州510640 [3]西南大学动物科学技术学院,重庆400700

出　　处：《动物营养学报》2025年第4期2697-2715,共19页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(U24A20447,32172777,32202730);广东省基础与应用基础研究基金(2022A1515011406,2021A1515110636);国家生猪产业技术体系(CARS-35);广东省乡村振兴战略专项资金(2023TS-3-1)。

摘　　要：为探究肠道损伤对断奶仔猪生长性能、血清和空肠炎症因子带来的影响,本试验对相关方面的研究进行了Meta分析。通过计算机对PubMed、Science Direct和Web of Science数据库进行检索,检索肠道损伤对断奶仔猪生长性能、血清和空肠炎症因子影响的随机对照试验。检索年限从2000年1月至2023年4月,设定样本纳入及排除标准进行文献筛选、数据提取,纳入总样本34篇,用Review Manager 5.4对纳入文献进行相关分析,效应指标选择标准化均数差(SMD)。结果显示:肠道损伤能够显著降低断奶仔猪平均日增重[SMD=-1.43,95%置信区间(CI)=(-1.71,-1.15),P<0.0001],降低平均日采食量[SMD=-1.08,95%CI=(-1.47,-0.69),P<0.0001],提高料重比[SMD=1.06,95%CI=(0.50,1.62),P=0.0002];肠道损伤显著提高空肠中白细胞介素-1β(IL-1β)[SMD=1.36,95%CI=(0.52,2.20),P=0.001]、肿瘤坏死因子-α(TNF-α)[SMD=0.76,95%CI=(0.22,1.30),P=0.006]、白细胞介素-6(IL-6)[SMD=0.79,95%CI=(0.26,1.32),P=0.004]以及血清中TNF-α[SMD=2.69,95%CI=(1.56,3.81),P<0.0001]的含量。这些结果表明,肠道损伤影响断奶仔猪的生长性能,损害免疫功能。In this experiment,a Meta-analysis was performed to investigate aspects related to the effects of intestinal injury on growth performance,serum and jejunal inflammatory factors in weaned piglets.A computerized search of PubMed,Science Direct and Web of Science databases was performed to retrieve randomized controlled trials on the effects of intestinal injury models on growth performance,serum and jejunal inflammatory factors in weaned piglets.The retrieval period was from January 2000-April 2023,and the sample inclusion and exclusion criteria were set for literature screening and data extraction,and a total sample of 34 papers was included.Correlation analyses of the included studies were performed with Review Manager 5.4,and standardized mean difference(SMD)was selected for the effect indicator.The Meta-analysis showed that intestinal injury significantly reduced the average daily gain of weaned piglets[SMD=-1.43,95%confidence interval(CI)=(-1.71,-1.15),P<0.0001],affected average daily feed intake[SMD=-1.08,95%CI=(-1.47,-0.69),P<0.0001],and increased feed/gain[SMD=1.06,95%CI=(0.50,1.62),P=0.0002].Moreover,intestinal injury models significantly increased jejunal interleukin-1β(IL-1β)[SMD=1.36,95%CI=(0.52,2.20),P=0.001],tumor necrosis factor-alpha(TNF-α)[SMD=0.76,95%CI=(0.22,1.30),P=0.006],and interleukin-6(IL-6)contents[SMD=0.79,95%CI=(0.26,1.32),P=0.004]and serum TNF-αcontent[SMD=2.69,95%CI=(1.56,3.81),P<0.0001].These results suggest that intestinal injury models affect growth performance and impairs immune function in weaned piglets.

关 键 词：肠道损伤模型 断奶仔猪 生长性能 炎症因子 META分析 

分 类 号：S828[农业科学—畜牧学]