双骨三子胶囊对气滞血瘀型老年骨质疏松性骨折术后疗效的影响研究  

Study on the effect of Shuanggu Sanzi capsule on the postoperative efficacy of elderly patients with osteoporotic fracture of qi stagnation and blood stasis type

作　　者：赖忠安 廖木贵 LAI Zhong-an;LIAO Mu-gui(Department of Orthopedics,Maoming Dianbai District People's Hospital,Maoming 525400,China)

机构地区：[1]茂名市电白区人民医院骨科,525400

出　　处：《中国现代药物应用》2025年第7期16-21,共6页Chinese Journal of Modern Drug Application

摘　　要：目的探讨双骨三子胶囊对气滞血瘀型老年骨质疏松性骨折术后患者临床效果、骨密度、骨代谢水平的影响。方法选取气滞血瘀型老年骨质疏松性骨折术后患者120例作为研究对象,随机分为对照组(60例)、观察组(60例)。对照组给予骨化三醇软胶囊治疗,观察组在对照组基础上给予双骨三子胶囊治疗。比较两组患者中医临床疗效,骨折愈合时间,治疗前后骨密度、骨代谢指标[血清骨钙素(OST)、骨特异性碱性磷酸酶(BAP)、Ⅰ型前胶原氨基端前肽(PⅠNP)、Ⅰ型胶原羧基末端肽(CTX)],不良反应发生情况。结果对照组总有效率为80.00%,观察组总有效率为93.33%,观察组高于对照组,差异有统计学意义(P<0.05)。观察组股骨骨折愈合时间(10.38±2.15)周、桡骨骨折愈合时间(7.19±2.06)周、胫骨骨折愈合时间(11.30±1.43)周及肱骨骨折愈合时间(7.26±1.48)周均短于对照组的(12.09±2.24)、(8.81±2.21)、(12.60±1.62)、(8.96±1.27)周,差异有统计学意义(P<0.05)。治疗前,两组患者骨密度相比差异无统计学意义(P>0.05)。治疗后,观察组骨密度(0.79±0.13)g/cm^(2)高于对照组的(0.70±0.10)g/cm^(2),差异有统计学意义(P<0.05)。治疗前,两组患者OST、BAP、PⅠNP及CTX相比差异无统计学意义(P>0.05)。治疗后,两组OST、BAP、PⅠNP水平高于治疗前,CTX水平低于治疗前,观察组OST、BAP、PⅠNP水平高于对照组,CTX水平低于对照组,差异有统计学意义(P<0.05)。观察组患者的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论双骨三子胶囊用于治疗气滞血瘀型老年骨质疏松性骨折术后患者,能明显提高中医临床疗效,增加骨密度,促进骨愈合,改善骨代谢水平,并能降低不良反应发生率。Objective To explore the effect of Shuanggu Sanzi capsule on clinical effect,bone density and bone metabolism level of elderly patients with osteoporotic fracture of qi stagnation and blood stasis type.Methods 120 patients with osteoporotic fracture of qi stagnation and blood stasis type were selected as the study subjects and randomly divided into control group(60 cases)and observation group(60 cases).The control group was treated with calcitriol capsules,and the observation group was treated with Shuanggu Sanzi capsule based on the control group.Both groups were compared in terms of clinical efficacy of traditional Chinese medicine,fracture healing time,bone mineral density,bone metabolism indexes[serum osteocalcin(OST),bone-specific alkaline phosphatase(BAP),amino-terminal propeptide of typeⅠprocollagen(PⅠNP),typeⅠcollagen carboxyl terminal peptide(CTX)]before and after treatment,and adverse reactions.Results The total effective rate was 80.00%in the control group and 93.33%in the observation group;the observation group was higher than the control group,and the difference was statistically significant(P<0.05).In the observation group,the femoral fracture healing time was(10.38±2.15)weeks,the radius fracture healing time was(7.19±2.06)weeks,the tibia fracture healing time was(11.30±1.43)weeks and the humerus fracture healing time was(7.26±1.48)weeks,which were shorter than(12.09±2.24),(8.81±2.21),(12.60±1.62)and(8.96±1.27)weeks in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in bone mineral density between the two groups(P>0.05).After treatment,the observation group had a higher bone mineral density of(0.79±0.13)g/cm^(2)than(0.70±0.10)g/cm^(2)in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in OST,BAP,PⅠNP and CTX between the two groups(P>0.05).After treatment,OST,BAP and PⅠNP levels in both groups were higher than those before t

关 键 词：老年 气滞血瘀型 骨质疏松性骨折 双骨三子胶囊 骨代谢指标 

分 类 号：R274.1[医药卫生—中医骨伤科学]