酮咯酸氨丁三醇治疗肾绞痛的疗效分析  

Analysis of the therapeutic effect of ketorolac tromethamine in the treatment of renal colic

作　　者：张辉 刘敬 曹振龙 ZHANG Hui;LIU Jing;CAO Zhen-long(Gaomi People's Hospital,Gaomi 261500,China)

机构地区：[1]高密市人民医院,261500

出　　处：《中国现代药物应用》2025年第7期102-105,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究酮咯酸氨丁三醇治疗肾绞痛的疗效。方法248例确诊为输尿管结石导致肾绞痛的患者,按照使用药物的不同分为酮咯酸氨丁三醇组(90例)、氟比洛芬酯组(80例)、吗啡组(78例)。比较三组患者用药前后不同时间点的数字疼痛评分法(NRS)评分,不良反应发生率,治疗效果。结果三组患者用药前后的NRS评分比较,差异存在统计学意义(P<0.05)。用药后15 min,酮咯酸氨丁三醇组的NRS评分(4.0±0.9)分明显低于氟比洛芬酯组的(5.2±1.4)分及吗啡组的(4.9±1.0)分,差异均存在统计学意义(P<0.05)。用药后1 h,酮咯酸氨丁三醇组的NRS评分(2.5±0.9)分明显低于氟比洛芬酯组的(2.9±0.8)分,差异存在统计学意义(P<0.05)。用药后6 h,酮咯酸氨丁三醇组的NRS评分(2.3±1.0)分明显低于氟比洛芬酯组的(2.9±1.2)分及吗啡组的(2.8±1.1)分,差异均存在统计学意义(P<0.05)。酮咯酸氨丁三醇组和氟比洛芬酯组的头晕发生率(2.2%、3.8%)、恶心呕吐发生率(3.3%、5.0%)均低于吗啡组(12.8%、19.2%),差异存在统计学意义(P<0.05)。酮铬酸氨丁三醇组的治疗有效率97.8%高于氟比洛芬酯组的90.0%及吗啡组的74.4%,氟比洛芬酯组的治疗有效率高于吗啡组,差异均存在统计学意义(P<0.05)。结论相比于氟比洛芬酯、吗啡,酮咯酸氨丁三醇能更快的达到止痛效果,并且止痛维持时间更长,不良反应发生率更低,可以作为急性止痛首选药物,适宜临床推广。Objective To study the therapeutic effect of ketorolac tromethamine in the treatment of renal colic.Methods A total of 248 patients diagnosed with renal colic caused by ureteral stones were randomly divided into ketorolac tromethamine group(90 cases),flurbiprofen axetil group(80 patients)and morphine group(78 patients).The numerical rating scale(NRS)scores at different time points before and after medication,incidence of adverse reactions,and treatment outcomes of three groups were compared.Results There was statistical significance in NRS scores before and after medication among the three groups(P<0.05).At 15 min after medication,the NRS score of ketorolac tromethamine group was(4.0±0.9)points,which was significantly lower than(5.2±1.4)points of flurbiprofen axetil group and(4.9±1.0)points of morphine group.The differences were statistically significant(P<0.05).At 1 h after medication,the NRS score of ketorolac tromethamine group was(2.5±0.9)points,which was significantly lower than(2.9±0.8)points of flurbiprofen axetil group,and the difference was statistically significant(P<0.05).At 6 h after administration,the NRS score of ketorolac tromethamine group was(2.3±1.0)points,which was significantly lower than(2.9±1.2)points of flurbiprofen axetil group and(2.8±1.1)points of morphine group,and the differences were statistically significant(P<0.05).The incidence of dizziness(2.2%,3.8%),nausea and vomiting(3.3%,5.0%)in ketorolac tromethamine group and flurbiprofen axetil group were lower than those in morphine group(12.8%,19.2%),and the differences were statistically significant(P<0.05).The effective rate of ketorolac tromethamine group was 97.8%,which was higher than that of flurbiprofen axetil group(90.0%)and morphine group(74.4%);the effective rate of flurbiprofen axetil group was higher than that of morphine group;the differences were statistically significant(P<0.05).Conclusion Compared with flurbiprofen axetil and morphine,ketorolac tromethamine can achieve the analgesic effect faster,and the pain relie

关 键 词：酮咯酸氨丁三醇 输尿管结石 肾绞痛 疗效 

分 类 号：R691.4[医药卫生—泌尿科学]