个体化呼吸功能康复训练对慢性阻塞性肺疾病急性发作期患者肺功能与生活质量的影响研究  

Study on impact of personalized respiratory rehabilitation training on lung function and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：苏小满 陈惠丹 SU Xiao-man;CHEN Hui-dan(Department of Respiratory and Critical Care Medicine,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361000,China)

机构地区：[1]厦门大学附属中山医院呼吸与危重症医学科,361000

出　　处：《中国现代药物应用》2025年第7期135-138,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究个体化呼吸功能康复训练对慢性阻塞性肺疾病(COPD)急性发作期患者肺功能、生活质量的影响。方法选择109例COPD急性发作期患者,随机分成对照组(54例)与干预组(55例)。对照组给予常规治疗与康复指导,干预组在对照组基础上增加个体化呼吸功能康复训练。比较两组患者肺功能指标[第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、最大呼气流量(PEF)、第1秒用力呼气容积占预计值百分比(FEV1%prep)]、血清炎症指标[C反应蛋白(CRP)、降钙素原(PCT)]、6 min步行距离(6MWD)、呼吸困难指数量表(mMRC)评分、慢性阻塞性肺疾病症状自我评估测试(CAT)评分。结果训练2周后,干预组患者的PEF(5.17±0.50)L/s、FEV1/FVC(76.45±7.38)%、FEV1%prep(78.29±7.51)%均显著高于对照组的(4.65±0.45)L/s、(68.21±6.59)%、(71.64±6.85)%(P<0.05)。训练2周后,干预组患者的CRP(8.79±0.84)mg/L、PCT(0.49±0.05)μg/L均显著低于对照组的(12.68±1.05)mg/L、(0.81±0.09)μg/L(P<0.05)。训练2周后,干预组患者的6MWD(453.18±42.05)m显著长于对照组的(384.72±34.91)m,mMRC评分(1.84±0.16)分、CAT评分(12.78±1.04)分均显著低于对照组的(2.05±0.18)、(16.54±1.30)分(P<0.05)。结论个体化呼吸功能康复训练有利于改善COPD急性发作期患者的肺功能和康复效果,减轻炎性反应,并且提高生活质量,具有较好的应用效果。Objective To study the impact of personalized respiratory rehabilitation training on lung function and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods 109 patients with acute exacerbation of COPD were selected and randomly divided into control group(54 cases)and intervention group(55 cases).The control group received routine treatment and rehabilitation guidance,while the intervention group received personalized respiratory rehabilitation training on the basis of the control group.Patients in both groups were compared in terms of lung function indicators[ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC),peak expiratory flow(PEF),and FEV1 as a percentage of the predicted value(FEV1%pred),serum inflammatory indicators[C-reactive protein(CRP)and procalcitonin(PCT)],6-min walking distance(6MWD),modified Medical Research Council(mMRC)score,and chronic obstructive pulmonary disease assessment test(CAT)score.Results After 2 weeks of training,the intervention group had PEF of(5.17±0.50)L/s,FEV1/FVC of(76.45±7.38)%,and FEV1%pred of(78.29±7.51)%,which were significantly higher than(4.65±0.45)L/s,(68.21±6.59)%,and(71.64±6.85)%in the control group(P<0.05).After 2 weeks of training,the intervention group had CRP of(8.79±0.84)mg/L and PCT of(0.49±0.05)μg/L,which were significantly lower than(12.68±1.05)mg/L and(0.81±0.09)μg/L in the control group(P<0.05).After 2 weeks of training,the intervention group had a significantly longer 6MWD of(453.18±42.05)m than(384.72±34.91)m in the control group;the intervention group had mMRC score of(1.84±0.16)points and CAT score of(12.78±1.04)points,which were significantly lower than(2.05±0.18)and(16.54±1.30)points in the control group(P<0.05).Conclusion Personalized respiratory rehabilitation training is beneficial for improving lung function and rehabilitation outcomes in patients with acute exacerbation of COPD,reducing inflammatory reactions,and improving quality of life,which has

关 键 词：个体化呼吸功能康复训练 慢性阻塞性肺疾病急性发作期 肺功能 生活质量 

分 类 号：R563.9[医药卫生—呼吸系统]