益生菌在种植体周炎中的作用及机制  

Role and mechanism of probiotics in peri-implantitis

作　　者：王杰 黄芮 张也 首朝曦 姚杰 刘辰希 廖健 Wang Jie;Huang Rui;Zhang Ye;Shou Zhaoxi;Yao Jie;Liu Chenxi;Liao Jian(School of Stomatology,Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Stomatological Hospital,Guizhou Medical University,Guiyang 550004,Guizhou Province,China)

机构地区：[1]贵州医科大学口腔医(学)院,贵州省贵阳市550004 [2]贵州医科大学附属口腔医院,贵州省贵阳市550004

出　　处：《中国组织工程研究》2026年第4期901-907,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(8226030370),项目负责人:廖健。

摘　　要：背景:已有研究发现益生菌对种植体周炎具有一定的防治作用,并在抗种植体周炎的机制研究方面也有进一步的探索。目的:综述益生菌在治疗种植体周炎中的作用机制及临床应用。方法:检索PubMed、Web of Science、中国知网、万方数据库中的相关文献,中文检索词为“益生菌,种植体周炎,菌群失调,免疫调节,炎症反应,微生态平衡”,英文检索词为“Probiotics,Peri-implantitis,Flora imbalance,Immunoregulation,Inflammatory reaction,Mechanism of action”,最终纳入90篇文献进行综述。结果与结论:益生菌具有以下作用机制:可以抑制炎症因子的分泌、促进抗炎因子的产生,从而激活抗炎机制;能够通过分泌微生物的复合物和细菌素来破坏致病菌的细胞壁,降低生物膜的pH值,改善微生态内微生物的组成,以诱导细菌群落结构的变化,从而恢复种植体周微生物群平衡;具有免疫调节作用,它们可以增强宿主口腔黏膜对种植体周围区域致病菌的抵抗力,还能产生抗菌化合物抵消致病微生物的黏附,调节免疫功能。通过上述机制,益生菌在种植体周炎的辅助治疗中具有一定的潜力,能够改善种植体周炎的临床参数并对微生物群产生影响。益生菌为防止种植体周炎提供了一种可供选择的治疗方法,但需要更多的长期前瞻性研究来进一步验证其作用效果。BACKGROUND:Studies have found that probiotics have a certain preventive and therapeutic effect on peri-implantitis,and there are further explorations in the mechanism against peri-implantitis.OBJECTIVE:To review the mechanism and clinical application of probiotics in the treatment of peri-implantitis.METHODS:Relevant literature was searched on PubMed,Web of Science,CNKI,and WanFang Data,using the search terms of“probiotics,peri-implantitis,flora imbalance,immunoregulation,inflammatory reaction,mechanism of action”in Chinese and English.A total of 90 articles were finally included.RESULTS AND CONCLUSION:Probiotics have the following mechanisms.They can activate the anti-inflammatory mechanism by inhibiting the secretion of inflammatory factors and promoting the production of anti-inflammatory factors.They can destroy the cell wall of pathogenic bacteria by secreting microbial complexes and bacteriocins,reduce the pH value of biofilms,improve the composition of microorganisms in microecology,induce the change of bacterial community structure,and restore the balance of microbial population around implants.They have immunomodulatory effects and can enhance the resistance of the host oral mucosa to pathogenic bacteria in the surrounding area of the implant.In addition,probiotics can produce antibacterial compounds,offset the adhesion of pathogenic microorganisms,and regulate immune function.Through the above mechanisms,probiotics have certain potential in the adjuvant treatment of peri-implantitis,which can improve the clinical parameters of peri-implantitis and affect the microbiota.Probiotic therapy provides a new treatment option,but more long-term prospective studies are needed to further verify its effect.

关 键 词：益生菌 种植体周炎 菌群失调 免疫调节 炎症反应 微生态平衡 工程化组织构建 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R78