巨噬细胞极化对2型糖尿病性骨质疏松症成骨-成血管偶联的影响  

Effect of macrophage polarization on osteogenesis-angiogenesis coupling in type 2 diabetic osteoporosis

作　　者：曹文琪 冯秀芝[1] 赵奕[1] 王智民[2] 陈怡然[1] 杨潇[3] 任艳玲[1] Cao Wenqi;Feng Xiuzhi;Zhao Yi;Wang Zhimin;Chen Yiran;Yang Xiao;Ren Yanling(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning Province,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110033,Liaoning Province,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning Province,China)

机构地区：[1]辽宁中医药大学,辽宁省沈阳市110847 [2]辽宁中医药大学附属医院,辽宁省沈阳市110033 [3]辽宁中医药大学附属第二医院,辽宁省沈阳市110034

出　　处：《中国组织工程研究》2026年第4期917-925,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(82174260),项目负责人:任艳玲;辽宁省科学技术厅联合基金博士科研启动项目(2023-BSBA-224),项目负责人:冯秀芝。

摘　　要：背景:2型糖尿病是骨质疏松症的继发性致病因素。巨噬细胞作为具有高度异质性的先天免疫细胞,能在高糖环境影响下发生极化,影响成骨-成血管偶联,这可能成为2型糖尿病性骨质疏松症患者改善骨骼质量的研究靶点。目的:探究调控巨噬细胞M1/M2极化影响成骨-成血管偶联对2型糖尿病性骨质疏松症的作用;总结临床常用的抗糖类、抗骨质疏松症类药物以及骨生物修复材料通过调控巨噬细胞M1/M2极化对骨骼成骨-成血管偶联的影响,以期为2型糖尿病性骨质疏松症的发病机制和治疗靶点提供新的思路。方法:以“巨噬细胞极化,2型糖尿病,骨质疏松症,成骨-成血管偶联”为中文检索词,以“macrophages、macrophage polarization、osteogenesis-angiogenesis coupling”为英文检索词,在CNKI和PubMed数据库中进行检索,对79篇文献进行筛选和整理、分析。结果与结论:(1)2型糖尿病使得体内处于高糖环境,机体内炎性相关因子分泌增加,促进巨噬细胞向M1极化,M2巨噬细胞数量减少;(2)在2型糖尿病中,促进M2巨噬细胞极化有利于成骨-成血管偶联;(3)部分抗糖类药物、中药及活性成分、骨生物修复材料可以通过调控巨噬细胞M1/M2极化,降低M1/M2比率,促进成骨-成血管偶联,从而改善2型糖尿病性骨质疏松症。BACKGROUND:Type 2 diabetes mellitus is a secondary causative factor for osteoporosis.As highly heterogeneous innate immune cells,macrophages may be polarized in a hyperglycemic environment,which affects osteogenesis-angiogenesis coupling.This may be a research target for improving bone quality in patients with type 2 diabetic osteoporosis.OBJECTIVE:To explore the role of modulating macrophage M1/M2 polarization to influence osteogenesis-angiogenesis coupling in type 2 diabetic osteoporosis and to summarize the effects of commonly used anti-glucose and anti-osteoporosis drugs and bone biorepair materials on bone osteogenesis-angiogenesis coupling by regulating macrophage M1/M2 polarization.METHODS:The keywords of“macrophage polarization,type 2 diabetes,osteoporosis,osteogenesis-angiogenesis coupling”in Chinese and“macrophages,macrophage polarization,osteogenesis-angiogenesis coupling”in English were used to search for relevant literature in CNKI and PubMed,respectively.Seventy-nine pieces of literature were screened and analyzed.RESULTS AND CONCLUSION:(1)Type 2 diabetes mellitus causes the body to be in a hyperglycemic environment and increases the secretion of inflammatory-related factors in the body,which promotes macrophage polarization towards M1 and decreases the number of M2 macrophages.(2)In type 2 diabetes,promoting M2 macrophage polarization is beneficial for osteogenesis-angiogenesis coupling.(3)Some anti-glycemic drugs,active ingredients in traditional Chinese medicine and bone biorepair materials can improve type 2 diabetic osteoporosis by regulating macrophage M1/M2 polarization,reducing M1/M2 ratio,and promoting osteogenesis-angiogenesis coupling.

关 键 词：巨噬细胞 巨噬细胞极化 2型糖尿病性骨质疏松症 成骨-成血管偶联 M1型巨噬细胞 M2型巨噬细胞 免疫调节 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R681