静电纺壳聚糖基纳米纤维支架在组织工程中的应用进展  

Application progress of electrospun chitosan-based nanofiber scaffold in tissue engineering

作　　者：孙亚宁[1] 杨雅雯 任炫丞 解晓君 吴韶华 李涛[1] SUN Yaning;YANG Yawen;REN Xuancheng;XIE Xiaojun;WU Shaohua;LI Tao(College of Textiles and Clothing,Qingdao University,Qingdao,266071,China;Qingdao Product Quality Testing Research Institute,Qingdao,266000,China)

机构地区：[1]青岛大学纺织服装学院,山东青岛266071 [2]青岛市产品质量检验研究院,山东青岛266000

出　　处：《棉纺织技术》2025年第5期20-28,共9页Cotton Textile Technology

基　　金：生物多糖纤维成形与生态纺织国家重点实验室课题(TSKT202102)。

摘　　要：为探索静电纺壳聚糖基纳米纤维支架在组织工程中的应用,梳理了影响静电纺丝的主要因素,介绍了静电纺丝技术制备壳聚糖基纳米纤维支架的基本方法,并综述了该支架在皮肤、软骨、骨、血管、神经等组织工程领域的应用效果。分析了壳聚糖基纳米纤维支架的物理微观结构特性、生物相容性与抗菌性原理,以及这些性能在组织工程中的应用研究进展。认为:壳聚糖基纳米纤维支架因其独特的纳米结构和生物相容性展现出巨大潜力,但目前真正应用于临床医学并实现设计功能还需持续研究探索。未来可从性能改进、临床转化与跨学科合作等方面着手,以期推动静电纺壳聚糖基纳米纤维支架在组织工程领域中的应用。To explore the application of electrospun chitosan-based nanofiber scaffold in tissue engineering,the main factors influencing electrospinning were outlined,and the basic methods for preparing these scaffolds using electrospinning technology were introduced.The application effectiveness of these scaffolds in tissue engineering fields such as skin,cartilage,bone,blood vessel,and nerve were reviewed.Additionally,the physical microstructural characteristic,biocompatibility,and antimicrobial property of the chitosan-based nanofiber scaffolds and the progress in applying these property in tissue engineering were analyzed.It is considered that chitosan-based nanofiber scaffolds have exhibited significant promise owing to their distinctive nanostructure and biocompatibility.Nevertheless,they still have remained in the investigational stage,necessitating additional research to comprehensively achieve their clinical utility and functional optimization.Future efforts should focus on improving performance,clinical translation and interdisciplinary collaboration,with the aim of advancing the application of electrospun chitosan-based nanofiber scaffolds in tissue engineering.

关 键 词：壳聚糖基纳米纤维 支架 静电纺丝 组织工程 生物医用纺织品 生物相容性 

分 类 号：TS101.8[轻工技术与工程—纺织工程]