静电纺纳米纤维/水凝胶复合结构支架在组织工程领域的研究进展  

Research progress on electrospun nanofiber/hydrogel composite scaffold in the field of tissue engineering

作　　者：潘佳璐 吴韶华 PAN Jialu;WU Shaohua(College of Textiles and Clothing,Qingdao University,Qingdao,266071,China)

机构地区：[1]青岛大学纺织服装学院,山东青岛266071

出　　处：《棉纺织技术》2025年第5期40-50,共11页Cotton Textile Technology

基　　金：生物多糖纤维成形与生态纺织国家重点实验室课题(TSKT202102)。

摘　　要：探讨静电纺纳米纤维/水凝胶复合结构支架的制备及其在组织工程领域的应用进展。分别介绍了层状结构、均质结构、壳核结构的静电纺纳米纤维/水凝胶复合结构支架及其制备策略,梳理了其在皮肤、神经、骨、软骨以及心血管组织工程中的应用。认为:静电纺纳米纤维/水凝胶复合结构支架既具有静电纺纳米纤维的先进细胞外基质仿形性,又具备水凝胶优异的吸液、保水性能以及仿生理化性能,使其在组织修复与再生中具有独特的优势。指出:目前静电纺纳米纤维/水凝胶复合结构支架在性能及产业化方面仍面临巨大挑战,如力学性能的优化、临床转化的可行性等,未来需要研究突破,以推动该复合结构支架在组织工程领域的进一步发展与应用。The preparation of electrospun nanofiber/hydrogel composite scaffold and their applications in tissue engineering were discussed.The electrospun nanofiber/hydrogel composite scaffold with laminated,homogeneous,and core-shell structure,as well as their preparation strategy were introduced.Their applications in skin,nerve,bone,cartilage and cardiovascular tissue engineering were outlined.It is considered that the electrospun nanofiber/hydrogel composite scaffold has the advanced extracellular matrix imitating characteristics of electrospun nanofiber with the excellent water absorption and retention property as well as biomimetic physicochemical property of hydrogel.It shows unique advantages in the tissue repair and regeneration.It is pointed out that there are still significant challenges regarding the performance and industrialization of these composite scaffolds,such as the optimization of mechanical property,the feasibility of clinical translation and so on.Research breakthroughs in these areas are needed in the future to promote the further development and application of electrospun nanofiber/hydrogel composite scaffold in tissue engineering.

关 键 词：静电纺丝 纳米纤维 水凝胶 复合支架 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]