静电纺纳米纤维支架用于肌腱损伤修复的研究进展  

Research progress of electrospun nanofiber-based scaffold for tendon repair

作　　者：刘小雨 陈韶娟[1] 吴韶华 LIU Xiaoyu;CHEN Shaojuan;WU Shaohua(College of Textiles and Clothing,Qingdao University,Qingdao,266071,China)

机构地区：[1]青岛大学纺织服装学院,山东青岛266071

出　　处：《棉纺织技术》2025年第5期51-57,共7页Cotton Textile Technology

基　　金：生物多糖纤维成形与生态纺织国家重点实验室课题(TSKT202102)。

摘　　要：为发挥静电纺丝技术制备的纳米纤维支架纤维直径小、孔隙率高、细胞外基质仿形好等独特优势,推进静电纺纳米纤维支架在肌腱组织工程领域的应用,基于静电纺丝技术改进、纺丝生物材料和生物活性分子选择、支架功能化改性以及多技术融合复合支架构建等,总结了静电纺丝基纳米纤维支架在肌腱组织损伤修复领域的最新研究进展,重点介绍了当前静电纺纳米纤维支架的构建策略,讨论了现阶段面临的主要挑战以及未来的发展趋势。认为:丰富支架的生物功能,改善支架的多尺度仿生形态结构、理化性能以及力学性能是目前静电纺丝技术构建新型肌腱组织工程用支架材料的研究热点。In order to take full advantage of the small fiber diameter,high porosity,and good ECM mimicry of nanofiber scaffold prepared by electrospinning technology,promote the application of electrospun nanofiber scaffold in the field of tendon tissue engineering,the latest progress of electrospun nanofiber scaffolds in the field of tendon tissue injury repair was summarized from the perspectives of electrospinning technology improvement,selection of biomaterial and bioactive molecule,functional modification of scaffold,and construction of multifunctional scaffold by integrating multiple technology.Current state-of-the-art strategies for constructing electrospun nanofiber scaffolds were focused.The main challenges faced at this stage and future development trends were discussed.It is considered that enriching the biological functions of scaffold,improving the multi-scale biomimetic morphology,physicochemical property,and mechanical property of scaffold are the research hotspots for developing new scaffold material in tendon tissue engineering using electrospinning technology.

关 键 词：医用纺织品 静电纺丝 纳米纤维支架 复合结构 肌腱再生 

分 类 号：TS101.8[轻工技术与工程—纺织工程]