Modular Synthesis of C_(2)-Symmetric Chiral TPy-BPI Pincer Ligands and Application in Asymmetric Ni(II)-Catalysed Friedel-Crafts Alkylation  

作　　者：Hong-Xing Cen Li-Ping Ding Lin-Lu Liu Wei-Dong Pan Xian-Qiao Zhu Wu-Wu Li Wen-Jing Zhang Li-Jun Peng Xiong-Li Liu 

机构地区：[1]National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food,Guizhou University,Guiyang,Guizhou,550025 China [2]Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an,Shaanxi,710062 China [3]Green Catalysis Center,and College of Chemistry,Zhengzhou University,Zhengzhou,Henan,450001 China

出　　处：《Chinese Journal of Chemistry》2025年第6期599-606,共8页中国化学(英文版)

基　　金：the financial support from the NSFC(22061006);Key Laboratory of Applied Surface and Colloid Chemistry(Shaanxi Normal University)of Ministry of Education,Natural Science Basic Research Plan in Shaanxi Province of China(No.2024JC-YBMS-119);Key Research and Development Plan Project of Xianyang(L2023-ZDYF-QYCX-030);Guizhou Provincial Basic Research Program(GCC[2023]078,ZK[2023]043,ZK[2022]144).

摘　　要：Comprehensive Summary Terpyridine ligands have been applied as a class of unique ligands due to their rich coordination chemistry in the catalysis.Herein,we developed a new class of C_(2)-symmetric chiral terpyridine-pyrroloimidazolone ligands(TPy-BPI).Their catalytic activity was evaluated in the asymmetric Friedel-Crafts alkylation of indoles with 2,3-dioxopyrrolidines.Excellent yields(up to 92%)and high enantioselectivities(up to 97%ee)are obtained for a wide range of substrates under mild conditions.

关 键 词：Pincer ligands Stereodirecting element Modular synthesis Asymmetric catalysis C_(2)-Symmetric ALKYLATION Synthesis design HETEROCYCLES 

分 类 号：O62[理学—有机化学]