Total Syntheses of Highly Oxidized Natural Products  

作　　者：Yan Wang Xiangbing Qi 

机构地区：[1]School of Life Sciences,Tsinghua University,Beijing,100084 China [2]National Institute of Biological Sciences,7 Science Park Road,Zhongguancun Life Science Park,Beijing,102206 China [3]Tsinghua Institute of Multidisciplinary Biomedical Research,Tsinghua University,Beijing,100084 China

出　　处：《Chinese Journal of Chemistry》2025年第6期650-714,共65页中国化学(英文版)

基　　金：supported by the National Natural Science Foundation of China(grant no.82225041,X.Q.).

摘　　要：Comprehensive Summary Natural products with high oxidation states and complex chemical skeletons exhibit diverse bioactivities due to their unique interactions with biological targets.The high oxidation state is characterized by the presence of multiple oxygen-containing functional groups such as hydroxyl groups,carbonyl groups,and epoxides that are usually tough to construct selectively.In recent years,thanks to the development of efficient strategies and sophisticated methodologies,significant advancements have been made in the total syntheses of highly oxidized natural products(HONPs).In this review,we highlight recent examples of HONPs focusing on tetrodotoxin(TTX)and its derivatives,steroidal alkaloids,sesquiterpenes,and diterpenoids since 2019.

关 键 词：Natural product High oxidation state Total synthesis 

分 类 号：O621.3[理学—有机化学]