Artificial Cell Wall:From Maintenance of Cell Viability to Boosting New Cellular Functionalities  

作　　者：Haoxiang Yuan Xin Qiao Shangsong Li Xiaoman Liu Xin Huang 

机构地区：[1]School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,Heilongjiang,150001 China

出　　处：《Chinese Journal of Chemistry》2025年第6期715-728,共14页中国化学(英文版)

基　　金：We thank NSFC(22377022,22171058 and 22475056);the Fundamental Research Funds for the Central Universities(HIT.0CEF.2023040);China-German Mobility Programme(M-0470)for financial support.

摘　　要：Comprehensive Summary Artificial cell wall(ACW)referring to active functional cellular nano-coatings is capable of providing more cell-shell synergic and cooperative properties than conventional single cell nanoencapsulation(SCNE).With the development of SCNE,the issues of cytocompatibility,degradability,etc.,have already been improved successively.However,the further emphasis on the cooperativity between the cell itself and its shell is still missing and paying more attention on the functions of cellular hybrids.Recent research proved that the construction of nano-coating on cells not only needs to satisfy the functionalization of the single cells,but also is necessary to empower cells to interact with other cells and environments.This indicates that SCNEs on cells are tending to be more“active”to participate in the metabolic process of cells and gradually develop to the stage of ACWs.This review provided a reasonable description of artificial cell wall,and the realization of this concept requires cooperativity,self-adaption and fluxionality.Then,the methodologies of constructing ACWs were discussed.Finally,the applications were summarized accompanied by the potential outlook in the given fields.

关 键 词：Artificial cell wall Single cell nanoencapsulation FLUXIONALITY Self-adaption SELF-ASSEMBLY Degradation Biomimetic synthesis 

分 类 号：R318[医药卫生—生物医学工程]