Conditional Tnfaip6‑Knockout in Inner Ear Hair Cells Does not Alter Auditory Function  

作　　者：Yue Qiu Song Gao Xiaoqiong Ding Jie Lu Xinya Ji Wenli Hao Siqi Cheng Haolinag Du Yajun Gu Chenjie Yu Cheng Cheng Xia Gao 

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,Jiangsu Provincial Key Medical Discipline(Laboratory),Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China [2]Department of Otolaryngology-Head and Neck Surgery,Zhongda Hospital,Southeast University,Nanjing 210008,China [3]Northern Jiangsu People’s Hospital Affiliated to Yangzhou University,Yangzhou 225001,China [4]Research Institute of Otolaryngology,Nanjing 210008,China

出　　处：《Neuroscience Bulletin》2025年第3期421-433,共13页神经科学通报(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(82192862,82371157,82201303,and 82271173);the Natural Science Foundation of Jiangsu Province(BE2023653,BK20230025,and BK20200133);the China Postdoctoral Science Foundation(2020M681555);a Distinguished Young Scholar supported by the Medical Science and Technology Development Foundation,Nanjing Department of Health(JQX20003).

摘　　要：Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity.This condition is closely linked to inflammatory responses,and interventions targeting the inflammatory gene tumor necrosis factoralpha(TNFα)are known to mitigate cochlear noise damage.TNFα-induced proteins(TNFAIPs)are a family of translucent acidic proteins,and TNFAIP6 has a notable association with inflammatory responses.To date,there have been few reports on TNFAIP6 levels in the inner ear.To elucidate the precise mechanism,we generated transgenic mouse models with conditional knockout of Tnfaip6(Tnfaip6 cKO).Evaluation of hair cell morphology and function revealed no significant differences in hair cell numbers or ribbon synapses between Tnfaip6 cKO and wild-type mice.Moreover,there were no notable variations in hair cell numbers or hearing function in noisy environments.Our results indicate that Tnfaip6 does not have a substantial impact on the auditory system.

关 键 词：Noise Tnfaip6 Hair cells Hearing loss 

分 类 号：R764.3[医药卫生—耳鼻咽喉科]