The Current State and Future Outlook of PET Tracers for AMPA Receptors  

作　　者：Ling Li Shenglin Wen Ji Dai 

机构地区：[1]Department of Psychology,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China [2]Shenzhen Technological Research Center for Primate Translational Medicine,Shenzhen-Hong Kong Institute of Brain Science,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]CAS Key Laboratory of Brain Connectome and Manipulation,The Brain Cognition and Brain Disease Institute,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [4]Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [5]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Neuroscience Bulletin》2025年第3期531-535,共5页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(32371066);the Guangdong Basic and Applied Basic Research Foundation(2022A1515010134);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019009);the Shenzhen Technological Research Center for Primate Translational Medicine(XMHT20220104005).

摘　　要：AMPA Receptor and PET Tracer Limitation.The alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid receptor(AMPAR)is a subtype of ionotropic glutamate receptor.It functions as a ligand-gated ion channel and is primarily responsible for rapidly transmitting the signal from glutamate in the central nervous system[1].This receptor plays a crucial role in various cognitive functions including learning,memory,cognition,synaptic plasticity,and neurodevelopment.AMPARs are typically composed of four subunits,namely GluA1,GluA2,GluA3,and GluA4,which can form homo-or hetero-tetramers.These subunits bind directly or indirectly to various scaffolding proteins such as transmembrane AMPA receptor regulatory proteins(TARPs).

关 键 词：pet tracer limitationthe synaptic plasticity cognitive functions pet tracers ampa receptors ampa receptor central nervous system ionotropic glutamate receptorit 

分 类 号：R817.4[医药卫生—影像医学与核医学]