Specific dendritic spine modifications and dendritic transport:From in vitro to in vivo  

作　　者：Albert H.K.Fok Charlotte H.M.Lam Cora S.W.Lai 

机构地区：[1]School of Biomedical Sciences,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China [2]Advanced Biomedical Instrumentation Center,Hong Kong Science Park,Shatin,New Territories,Hong Kong Special Administrative Region,China [3]The State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,Hong Kong Special Administrative Region,China [4]Center for Research in Neuroscience,Department of Neurology&Neurosurgery,Brain Repair and Integrative Neuroscience Program,The Research Institute of the McGill University Health Centre,Montreal,QC,Canada

出　　处：《Neural Regeneration Research》2026年第2期665-666,共2页中国神经再生研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(NSFC/RGC/JRF N_HKU735/21);Research Grant Council of Hong Kong,China(17102120,17108821,17103922,C1024-22GF,C7074-21G);Health and Medical Research Fund(HMRF 09200966)(to CSWL);FRQS Postdoctoral Fellowship(to AHKF).

摘　　要：Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.

关 键 词：excitatory synapses principal neuronsplaying compartmentalized environment establish maintain synapses cornejo dendritic spines regulate calcium signal dynamicsallowing regulation protein expression dendritic shaft 

分 类 号：R338[医药卫生—人体生理学]