围绝经期人群焦虑和抑郁状态与双膦酸盐治疗依从性和骨密度变化的相关性  

Correlation analysis of anxiety and depression with bisphosphonate treatment complianceand bone mineral density changes in perimenopausal population

作　　者：张爱慕 刘三微 施展宏 周帆 ZHANG Aimu;LIU Sanwei;SHI Zhanhong;ZHOU Fan(Department of Obstetrics and Gynecology,Wenzhou Central Hospital,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州市中心医院妇产科,浙江温州325000

出　　处：《中华全科医学》2025年第5期819-822,共4页Chinese Journal of General Practice

基　　金：浙江省中医药科技计划项目(2024ZL997);温州市基础性医疗卫生科技项目(Y20210357)。

摘　　要：目的 分析围绝经期人群焦虑和抑郁状态与双膦酸盐治疗依从性和骨密度(BMD)变化的相关性,为早期干预该类人群焦虑和抑郁提供依据。方法 采用便利抽样法抽取温州市中心医院2022年2月—2024年2月期间诊治的248例围绝经期女性,采用Zung焦虑自评量表(SAS)和Zung抑郁自评量表(SDS)评估研究对象的焦虑抑郁状态,根据结果将其分为焦虑抑郁发生组(SAS评分≥50分和SDS评分≥53分)和未发生组。分析比较2组一般资料、双膦酸盐治疗依从性以及BMD水平,采用多因素logistic回归分析研究影响围绝经期女性焦虑抑郁状态的因素;同时将焦虑抑郁发生组按照SAS、SDS评分分为轻、中、重度,采用Pearson检验分析患者焦虑抑郁评分与双膦酸盐治疗依从性及骨密度变化的相关性。结果 完成调查的245例围绝经期女性中有71例发生焦虑抑郁,发生率为28.98%。多因素logistic回归分析显示,高BMI、无配偶、高围绝经期症状严重程度评分均为围绝经期女性发生焦虑抑郁的独立危险因素,无慢性病、用药依从性高、高BMD是围绝经期女性发生焦虑抑郁的独立保护因素。围绝经期女性焦虑评分与双膦酸盐治疗依从性、BMD变化均呈负相关关系。结论 围绝经期人群焦虑抑郁发生率较高,且与双膦酸盐治疗依从性和BMD变化呈负相关关系。Objective To analyze the correlation between anxiety and depression in the perimenopausal population,compliance with bisphosphonate treatment and changes in bone mineral density(BMD),and to provide evidence for early intervention of anxiety and depression in women.Methods A total of 248 perimenopausal women diagnosed and treated in Wenzhou Central Hospital from February 2022 to February 2024 were selected by convenient sampling method,and their anxiety and depression were evaluated by Zung self-rating anxiety scale(SAS)and Zung self-rating depression scale(SDS).According to the results,they were divided into an anxiety and depression group(SAS score≥50 and SDS score≥53)and a non-anxiety and depression group.The general data,bisphosphonate treatment compliance,and BMD of the two groups were analyzed and compared,and the related factors affecting the patients'anxiety and depression were analyzed by multivariate logistic regression.At the same time,the anxiety and depression group was divided into mild,moderate,and severe according to the SAS score and SDS score.Pearson test was used to analyze the correlation between anxiety and depression scores and bisphosphonate treatment compliance,and BMD changes in perimenopausal women.Results Among the 245 perimenopausal patients who completed the investigation,71 cases developed anxiety and depression,with an incidence rate of 28.98%.By multivariate logistic regression analysis,high BMI,no spouse,and high perimenopausal symptom severity score were independent risk factors for anxiety and depression in perimenopausal women,while no chronic disease,high medication compliance,and high BMD were independent protective factors for anxiety and depression in perimenopausal women.Anxiety score of perimenopausal women was negatively correlated with bisphosphonate treatment compliance and BMD changes.Conclusion The incidence of anxiety and depression in the perimenopausal population is high,which is negatively correlated with the compliance of bisphosphonate treatment and the chan

关 键 词：围绝经期 焦虑 抑郁 双膦酸盐治疗依从性 骨密度 相关性 

分 类 号：R173.4[医药卫生—妇幼卫生保健] R711.75[医药卫生—公共卫生与预防医学]