DeVita超声评分联合SWE在原发性干燥综合征腮腺损害中的诊断价值  

Diagnostic value of shear wave elastography combined with DeVita ultrasonic scorein assessment of parotid gland lesions of Sj gren ' s syndrome

作　　者：焦兰兰 李阳 王兵 王信 隋洋 孟飞逸 JIAO Lanlan;LI Yang;WANG Bing;WANG Xin;SUI Yang;MENG Feiyi(Graduate School of Bengbu Medical University,Bengbu,Anhui 233000,China;不详)

机构地区：[1]蚌埠医科大学研究生院,安徽蚌埠233000 [2]蚌埠医科大学第一附属医院超声医学科,安徽蚌埠233004 [3]蚌埠医科大学第一附属医院风湿免疫科

出　　处：《中华全科医学》2025年第5期827-830,共4页Chinese Journal of General Practice

基　　金：安徽省高校自然科学研究重点项目(2022AH051494);安徽省卫生健康科研项目(AHWJ2023A20372)。

摘　　要：目的 探讨DeVita超声评分联合剪切波弹性成像(SWE)在原发性干燥综合征(pSS)腮腺损害中的临床诊断价值,并分析二者与抗SSA和抗SSB抗体之间的相关性。方法 选取2023年4月—2024年6月蚌埠医科大学第一附属医院风湿免疫科收治的pSS患者64例作为pSS组,另选择同期30名健康者作为对照组。采用常规二维超声观察腮腺形态学特征,并进行超声评分,SWE模式下获取腮腺杨氏模量平均值(Emean)。分别评估腮腺超声评分、Emean单独及两者联合在原发性干燥综合征腮腺病变中的诊断价值,并分析两者与血清学指标抗SSA和抗SSB抗体表达之间的相关性。结果 pSS组与对照组超声评分比较,差异有统计学意义(P<0.05);pSS组腮腺和对照组腮腺Emean比较,差异有统计学意义(P<0.05)。ROC曲线显示,超声评分、SWE及两者联合评估腮腺损害的AUC分别为0.728、0.884和0.904,联合预测的AUC优于超声评分和SWE单独预测。抗SSA/SSB抗体表达与超声评分及SWE均相关(P<0.05)。结论 超声评分联合SWE在原发性干燥综合征腮腺损害中具有一定的临床预测价值。Objective To investigate the clinical value of DeVita ultrasound scoring in collaboration with shear wave elastography(SWE)in parotid gland damage in primary Sj gren's syndrome(pSS),and to analyze their correlation with anti-SSA and anti-SSB antibodies.Methods A total of 64 patients diagnosed with primary Sj gren's syndrome(pSS)and admitted to the Department of Rheumatology and Immunology of the First affiliated Hospital of Bengbu Medical University,constituted the experimental group during the period from April 2023 to June 2024.In contrast,30 healthy subjects were collected as the control group.The morphological characteristics of the parotid gland were obtained by means of routine ultrasound,after which ultrasound scoring was performed.The mean value of primary parotid Young's modulus(Emean)was obtained under SWE mode to evaluate the diagnostic value of parotid ultrasound score Emean alone and the combination of Emean in parotid damage of Sj gren's syndrome.Furthermore,the correlation between the above two groups of parameters and serological indicators of anti-SSA and anti-SSB antibodies expression was explored.Results A statistically significant discrepancy was identified in the ultrasound scores between the patients diagnosed with pSS and the subjects in control group(P<0.05).A similar statistically significant discrepancy was identified in the parotid mean Emean values between the pSS patients and the control group(P<0.05).ROC curve analysis revealed that the AUC of ultrasound score,SWE and the combined assessment of parotid lesions were 0.728,0.884 and 0.904,respectively,and the AUC of the two was superior to that of ultrasound score and SWE.A significant correlation was identified between the expression of anti-SSA/SSB antibodies and ultrasound scores,as well as and SWE(P<0.05).Conclusion The integration of SWE with ultrasound scoring has been demonstrated to possess a certain degree of clinical application value in the context of parotid lesions associated with of primary Sj gren's syndrome.

关 键 词：原发性干燥综合征 剪切波弹性成像 DeVita评分 腮腺 抗SSA抗体 抗SSB抗体 

分 类 号：R593.2[医药卫生—内科学] R445.1[医药卫生—临床医学]