铜死亡与铜代谢在自身免疫性疾病中的研究进展  

Advancements in the study of cuproptosis and copper metabolism in autoimmune diseases

作　　者：弓雪妍 刘洋[1] 苏雅珍 张莉芸[1] GONG Xueyan;LIU Yang;SU Yazhen;ZHANG Liyun(Third Hospital of Shanxi Medical University,Department of Immunology&Rheumatology,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan,Shanxi 030032,China)

机构地区：[1]山西医科大学第三医院,山西白求恩医院风湿免疫科,山西医学科学院,山西太原030032

出　　处：《中华全科医学》2025年第5期844-847,共4页Chinese Journal of General Practice

基　　金：山西省基础研究计划自然科学研究面上项目(202103021224342);山西省基础研究计划自然科学研究青年项目(202303021222313);山西省高等学校科技创新项目(2023L076)。

摘　　要：自身免疫性疾病(autoimmune diseases, AIDs)是一类由机体免疫系统异常攻击自身正常组织和细胞而引发的疾病。这类疾病涉及多个器官系统,对人体健康造成巨大危害。目前,自身免疫性疾病影响全球约5%的人群,给患者和社会造成了严重的经济负担。然而,迄今为止,AIDs的发病机制仍然不明确,且现有治疗手段疗效有限。最近的研究表明,AIDs与线粒体功能障碍密切相关,而铜死亡作为一种新表征的细胞死亡形式,与线粒体呼吸密切相关,提示铜死亡可能在AIDs的发生和发展中发挥着重要的作用。自20世纪上半叶以来,铜的生物学作用始终是生命科学领域的研究热点。最近的研究发现,铜代谢会影响免疫系统的功能,铜代谢的失衡与炎症的进展和免疫反应有关。本文从铜死亡及铜代谢在AIDs中的生理作用、干预机制及生信研究等方面进行总结,系统评述其在类风湿关节炎(rheumatoid arthritis, RA)、系统性红斑狼疮(systemic lupus erythematosus, SLE)等AIDs,及其他疾病如骨关节炎(osteoarthritis, OA)中的机制与作用,系统梳理铜死亡与铜代谢在AIDs中的研究进展,为AIDs的治疗提供新的思路和可能性。Autoimmune diseases(AIDs)are a group of disorders characterized by the abnormal attack of the body's immune system on its own tissues and cells.These diseases affect multiple organ systems and pose a significant threat to human health.Currently,AIDs affect approximately 5%of the global population,leading to significant economic burdens.However,the etiology of AIDs remains unclear,and existing treatment modalities are still limited in efficacy.Recent studies indicate a close association between AIDs and mitochondrial dysfunction.Cuproptosis,a newly characterized form of cell death closely related to mitochondrial respiration,suggests a potentially significant role in the onset and progression of AIDs.Since the first half of the 20th century,the biological roles of copper have remained a focal point of sustained scientific investigation in life sciences.Recent studies have shown that copper metabolism affects the functionality of the immune system and is associated with the progression of inflammation and immune responses.This paper provides a summary of the biological functions,intervention mechanisms,and bioinformatics research of cuproptosis and copper metabolism in AIDs.It systematically reviews their roles and mechanisms in AIDs such as rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),and other diseases like osteoarthritis(OA),systematically examining the research progress of copper death and copper metabolism in AIDs.By thoroughly understanding the relationship of cuproptosis,copper metabolism,and AIDs,new therapeutic targets and approaches may be discovered,providing novel insights and possibilities for the treatment of AIDs.

关 键 词：自身免疫性疾病 铜代谢 铜死亡 

分 类 号：R593[医药卫生—内科学]