自拟补肾养肝汤加减联合定坤丹用于卵巢早衰患者的临床研究  

Clinical study on self-made Bushen Yanggan Decoction combined withDingkundan in the treatment of premature ovarian failure

作　　者：何菊[1] 沈丹[2] HE Ju;SHEN Dan(Department of Gynecology,Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing,Zhejiang 312000,China;不详)

机构地区：[1]绍兴市中医院妇科,浙江绍兴312000 [2]杭州市中医院妇科,浙江杭州310000

出　　处：《中华全科医学》2025年第5期853-857,共5页Chinese Journal of General Practice

基　　金：浙江省中医药科技计划项目(2022ZB234)。

摘　　要：目的 探讨自拟补肾养肝汤加减联合定坤丹对卵巢早衰患者性激素、糖脂代谢水平变化的影响,并分析其在提高患者生活质量方面的作用。方法 根据采取的治疗方案将2022年6月—2024年3月于绍兴市中医院接受治疗的97例卵巢早衰患者分为西医组(48例)和中医组(49例),西医组给予西医激素治疗,中医组给予口服定坤丹联合自拟补肾养肝汤加减治疗。比较2组患者治疗后的中医证候疗效、性激素、糖脂代谢水平变化、生活质量等。结果 中医组的治疗总有效率高于西医组[91.84%(45/49)vs. 75.00%(36/48),χ^(2)=4.990,P=0.025];中医组的HbA1c[(4.84±0.80)%vs.(5.18±0.73)%,P<0.05]等糖脂代谢指标水平均低于西医组;中医组促黄体生成素/卵泡刺激素值(1.93±0.65 vs. 3.00±0.91)低于西医组(P<0.001);中医组的生活质量得分在治疗4周[(69.22±7.21)分vs.(64.29±8.02)分]、8周[(80.29±8.63)分vs.(70.63±6.34)分]、12周[(86.39±4.15)分vs.(72.33±4.38)分]后均高于西医组(P<0.05)。结论 自拟补肾养肝汤加减联合定坤丹在改善卵巢早衰患者性激素、糖脂代谢水平以及生活质量方面存在明显、持续性的益处,且安全性较高,值得在临床推广。Objective To explore the effect of self-made Bushen Yanggan Decoction combined with Dingkundan on the changes of sex hormones and glucose and lipid metabolism in patients with premature ovarian insufficiency,and analyze its role in improving the quality of life of patients.Methods A total of 97 cases of premature ovarian insufficiency treated in Shaoxing Hospital of Traditional Chinese Medicine from June 2022 to March 2024 were selected as the research object,and divided into western medicine(WM)group(48 cases)and traditional Chinese medicine(TCM)group(49 cases)according to the treatment regimen taken.The WM group received hormone therapy from western medicine,while the TCM group was treated with Dingkundan combined with self-made Bushen Yanggan Decoction.The curative effect of TCM syndrome,changes of sex hormones,glucose and lipid metabolism level and quality of life were compared between the two groups after treatment.Results The total effective rate of TCM group was higher than that of WM group[91.84%(45/49)vs.75.00%(36/48),χ^(2)=4.990,P=0.025].HbA1c[(4.84±0.80)%vs.(5.18±0.73)%,P<0.05]and other glucose and lipid metabolism levels in TCM group were lower than those in WM group.The luteinizing hormone/follicular stimulating hormone ratio of TCM group(1.93±0.65 vs.3.00±0.91)was lower than that of WM group(P<0.001).The quality of life scores in TCM group were significantly higher than those in WM group at 4 weeks[(69.22±7.21)points vs.(64.29±8.02)points],8 weeks[(80.29±8.63)points vs.(70.63±6.34)points],and 12 weeks[(86.39±4.15)points vs.(72.33±4.38)points]after treatment(P<0.05).Conclusion Self-made Bushen Yanggan Decoction combined with Dingkundan has obvious and sustained benefits in improving sex hormones,glucose and lipid metabolism and quality of life in patients with premature ovarian failure,and it is safe and worthy of clinical promotion.

关 键 词：卵巢早衰 定坤丹 补肾养肝汤加减 生活质量 糖脂代谢 性激素 

分 类 号：R711.75[医药卫生—妇产科学] R289.5[医药卫生—临床医学]