2型糖尿病患者应用达格列净联合胰岛素强化的治疗效果及对其血糖指标的影响  

The Therapeutic Effect of Daggligin Combined with Insulin Intensification in Patients with Type 2 Diabetes and its Influence on Blood Glucose Indicators

作　　者：王瑛瑛 WANG Yingying(Department of Endocrinology,Second People's Hospital of Zhangye City,Zhangye,Gansu 734000)

机构地区：[1]甘肃省张掖市第二人民医院内分泌科,甘肃张掖734000

出　　处：《智慧健康》2025年第5期78-81,共4页Smart Healthcare

摘　　要：目的 本研究旨在系统评估达格列净与胰岛素强化治疗结合在2型糖尿病(T2DM)患者治疗中的疗效。方法 选取本院于2022年8月—2023年10月收治的70例T2DM患者,通过随机数字表法分为对照组(采用胰岛素强化治疗)与观察组(实施达格列净列净片联合胰岛素强化治疗),每组35例。对比分析不同治疗方案的临床效果。结果 治疗后,观察组的血糖指标糖化血红蛋白[(6.36±1.22)%、空腹血糖(5.90±1.25)mmol/L、餐后2h血糖(7.23±1.22)mmol/L]较对照组有所下降(P<0.05)。观察组的LDL-C和TG水平[(2.30±0.42)mmol/L、(1.98±0.46)mmol/L]均较对照组[(2.55±0.53)mmol/L、(2.42±0.53)mmol/L]下降显著,观察组的HDL-C(1.33±0.22)mmol/L水平的上升幅度高于对照组(1.15±0.24)mmol/L(P<0.05)。观察组的MBG、SDBG、LAGE以及PPGE[(9.34±2.63)mmol/L、(1.90±0.34)mmol/L、(3.45±0.66)mmol/L、(2.80±0.55)mmol/L]均低于对照组[(10.80±3.05)mmol/L、(2.47±0.52)mmol/L、(4.92±0.97)mmol/L、(3.34±0.66)mmol/L(P<0.05)]。结论 在治疗T2DM患者中达格列净联合胰岛素强化治疗方案展现了卓越的治疗成效,是一种值得推荐的T2DM治疗方案。Objective The purpose of this study is to systematically evaluate the efficacy of dagglinide combined with intensive insulin therapy in the treatment of type 2 diabetes mellitus (T2DM).Methods 70 T2DM patients admitted to our hospital from August 2022 to October 2023 were randomly divided into a control group (treated with insulin intensification therapy) and an observation group (treated with dapagliflozin tablets combined with insulin intensification therapy) using a random number table method,with 35 patients in each group.Compare and analyze the clinical effects of different treatment plans.Results The blood glucose indicators of the observation group[(6.36±1.22)%,(5.90±1.25) mmol/L,(7.23±1.22) mmol/L]decreased compared to the control group[(7.89±1.66)%,(7.88±2.13) mmol/L,(9.79±1.23) mmol/L](P<0.05).The levels of LDL-C and TG in the observation group[(2.30±0.42) mmol/L,(1.98±0.46) mmol/L]were significantly lower than those in the control group[(2.55±0.53) mmol/L,(2.42±0.53) mmol/L],and the increase in HDL-C (1.33±0.22) mmol/L level in the observation group was higher than that in the control group (1.15±0.24) mmol/L (P<0.05).The MBG,SDBG,LAGE,and PPGE levels in the observation group[(9.34±2.63) mmol/L,(1.90±0.34) mmol/L,(3.45±0.66) mmol/L,(2.80±0.55) mmol/L]were lower than those in the control group[(10.80±3.05) mmol/L,(2.47±0.52) mmol/L,(4.92±0.97) mmol/L,(3.34±0.66) mmol/L,(P<0.05)].Conclusion The combination of dapagliflozin and intensive insulin therapy has demonstrated excellent therapeutic efficacy in the treatment of T2DM patients and is a recommended treatment option for T2DM.

关 键 词：达格列净 胰岛素强化治疗 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]