登革热相关性吉兰-巴雷综合征1例  

A case report of Guillain-Barrésyndrome associated with dengue fever

作　　者：林伟 苏巧珍[2] 陈宇锋[3] 郑春叶[2] LIN Wei;SU Qiaozhen;CHEN Yufeng;ZHENG Chunye(The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 519405,China)

机构地区：[1]广州中医药大学第二附属医院 [2]广州中医药大学第二临床医学院,广州510405 [3]南通市第三人民医院

出　　处：《中国神经精神疾病杂志》2025年第3期162-164,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省中医院名中医药专家学术经验传承工作室项目(编号:中医二院【2014】89号)。

摘　　要：报告1例19岁男性患者,登革热发病后出现四肢麻木乏力、双侧面瘫、吞咽困难,言语不清,体格检查见双膝以下深浅感觉减退,四肢腱反射消失。脑脊液蛋白结果正常,神经节苷脂相关抗体阴性,肌电图提示四肢及面神经多发对称性周围神经脱髓鞘损害,诊断为吉兰-巴雷综合征,予以免疫球蛋白及激素治疗后症状好转,随访患者恢复良好。登革热在国内吉兰-巴雷综合征前驱感染中报告较少。本报道旨在通过该病例的临床诊治过程分析及相关文献复习,提高对此类疾病诊治的认识。提示临床医师早期诊断与治疗,避免误诊漏诊。We report a 19-year-old male patient who developed numbness and weakness in the extremities,bilateral facial paralysis,difficulty swallowing,and slurred speech after the onset of dengue fever.Physical examination revealed decreased superficial and deep sensation below the knees,with absent tendon reflexes in the limbs.Cerebrospinal fluid analysis was normal,and ganglioside-related antibodies were negative.Electromyography showed multiple symmetric peripheral nerve demyelination in the limbs and facial nerves.The patient was diagnosed with Guillain-Barrésyndrome.After receiving treatment with immunoglobulin and corticosteroids,his symptoms improved,and he made a good recovery during follow-up.Dengue fever has been rarely reported as a preceding infection of Guillain-Barrésyndrome in China.This case report,along with a review of relevant literature,aims to enhance the understanding of the diagnosis and management of this condition.It emphasizes the importance of early diagnosis and treatment by clinicians to avoid misdiagnosis and missed diagnosis of dengue-related Guillain-Barrésyndrome.

关 键 词：吉兰-巴雷综合征 登革热 脱髓鞘疾病 案例报道 临床特征 

分 类 号：R599.4[医药卫生—内科学] R743.3[医药卫生—临床医学]