中国四省份丙型肝炎病例知晓HCV感染状况与核酸检测意愿调查  

Awareness of HCV infection status and willingness for ribonucleic acid testing among hepatitis C cases in four provinces in China

作　　者：虞接军 张小斌[2] 李宁[3] 汤恒[4] 叶少东[1] 李健[1] 刘中夫[1] 杨丹丹[5] 韩晶[1] Yu Jiejun;Zhang Xiaobin;Li Ning;Tang Heng;Ye Shaodong;Li Jian;Liu Zhongfu;Yang Dandan;Han Jing(Division of HCV/STD Prevention and Treatment,National Center for STD/AIDS Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Institute of STD/AIDS Control and Prevention,Yunnan Provincial Center for Disease Control and Prevention,Kunming 650034,China;Institute of STD/AIDS Prevention and Treatment,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China;Institute for Infectious Disease Control and Prevention,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China;Institute of STD/AIDS Control and Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心丙型肝炎与性病防治室,北京102206 [2]云南省疾病预防控制中心性病艾滋病防制所,昆明650034 [3]河南省疾病预防控制中心性病艾滋病防治研究所,郑州450016 [4]湖北省疾病预防控制中心传染病防治研究所,武汉430079 [5]江苏省疾病预防控制中心性病与艾滋病防制所,南京210009

出　　处：《中华流行病学杂志》2025年第4期688-694,共7页Chinese Journal of Epidemiology

基　　金：丙型肝炎防治技术指导与能力建设项目(131031105000200002)。

摘　　要：目的分析中国四省份丙型肝炎(丙肝)病例知晓HCV感染状况与核酸即HCV-RNA检测意愿,为调整丙肝的防控策略提供参考依据。方法2021年9月至2022年9月在中国四省份(江苏、河南、湖北和云南)采用分层随机整群抽样的方法,开展横断面调查,估计样本量为6468例。问卷收集的内容包括调查对象的社会人口学信息、知晓HCV感染状况、HCV-RNA检测意愿、高风险行为史等。采用logistic回归模型分析丙肝病例知晓HCV感染状况、HCV-RNA检测意愿的相关因素。应用R 4.1.3软件进行统计学分析。结果共调查丙肝病例10563例,知晓HCV感染的比例为86.74%(9162/10563),有HCV-RNA检测意愿的比例为85.21%(9001/10563)。多因素logistic回归模型分析显示,年龄≥60岁、城镇居民/新型农村合作医疗保险、无输血史、无有偿献血史、无注射吸毒史、家庭成员中无丙肝病例者知晓HCV感染的比例更低;高中/中专及以上文化程度者、已婚有配偶者知晓HCV感染的比例更高(均P<0.05)。在HCV-RNA检测意愿方面,女性、年龄≥60岁、无输血史、无有偿献血史、无注射吸毒史者的HCV-RNA检测意愿较低;农民/民工、企业/事业单位职工、其他职业者的HCV-RNA检测意愿较高(均P<0.05)。结论中国四省份丙肝病例知晓HCV感染比例和HCV-RNA检测意愿仍有提升空间,应制定更多便利政策和措施提高病例知晓HCV感染比例和HCV-RNA检测意愿。Objective To analyze the awareness of HCV infection status and willingness for HCV-RNA testing among hepatitis C cases in four provinces in China and to provide a reference for adjusting HCV prevention and control strategies.Methods From September 2021 to September 2022,a cross-sectional survey was conducted using stratified random cluster sampling in four provinces(Jiangsu,Henan,Hubei,and Yunnan)in China,with an estimated sample size of 6468 participants.The questionnaire included sociodemographic information,HCV infection awareness,willingness for HCV-RNA testing,and history of high-risk behaviors from the survey participants.Logistic regression models were used to analyze the factors associated with HCV infection awareness and willingness for HCV-RNA testing among hepatitis C cases.Statistical analysis was performed using R 4.1.3 software.Results A total of 10563 hepatitis C cases were surveyed.The awareness rate of HCV infection was 86.74%(9162/10563),and the willingness rate for HCV-RNA testing was 85.21%(9001/10563).Multivariate logistic regression models analysis showed that the awareness rate of HCV infection was lower among individuals aged≥60 years,urban residents(with New Rural Cooperative Medical Insurance),those without a history of blood transfusion,those without a history of paid blood donation,those without a history of injection drug use,and those without a family member with hepatitis C case.The awareness rate was higher among individuals with high or technical secondary school education,college education or above,and those married with a spouse(all P<0.05).In terms of willingness for HCV-RNA testing,it was lower among females,individuals aged≥60 years,and those without a history of blood transfusion,paid blood donation,or injection drug use.The willingness was higher among farmers or migrant workers,employees of enterprises or institutions,and those in other occupations(all P<0.05).Conclusions There was room for improvement in the awareness proportion of HCV infection and willingness for HC

关 键 词：丙型肝炎 丙型肝炎病毒 知晓 核糖核酸 检测意愿 

分 类 号：R512.6[医药卫生—内科学]