中国HIV/AIDS患者血脂异常患病率的Meta分析  

Prevalence of Dyslipidemia in Chinese Patients with HIV/AIDS:A Meta-Analysis

作　　者：田海萍 乔婉婉 温贤秀[2] Tian Haiping;Qiao Wanwan;Wen Xianxiu(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075;Department of Nursing,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China)

机构地区：[1]成都中医药大学护理学院,四川成都610075 [2]四川省医学科学院·四川省人民医院(电子科技大学附属医院)护理部,四川成都610072

出　　处：《四川医学》2025年第4期397-404,共8页Sichuan Medical Journal

摘　　要：目的系统评价国内HIV/AIDS患者血脂异常患病率。方法计算机检索PubMed、Web of Science、Cochrane Library、Embase、CINAHL、中国知网、万方数据库、维普数据库及中国生物医学文献数据库,搜集与研究目的相关研究,检索时限为建库至2024年12月。由2名研究者独立筛选文献、提取数据及质量评价,采用Stata 14.0进行Meta分析。结果最终纳入15篇研究,总样本量为24497例,偏倚风险质量评分为7~9分,均为中等或高质量。Meta分析结果显示,中国HIV/AIDS患者血脂异常的总患病率为51.4%(95%CI 39.3%~63.4%),高总胆固醇血症患病率为8.7%(95%CI 4.7%~13.7%),高甘油三酯血症患病率为26.0%(95%CI 19.3%~33.4%),高低密度脂蛋白胆固醇血症患病率为10.4%(95%CI 5.4%~16.8%),低高密度脂蛋白胆固醇血症患病率为39.9%(95%CI 30.7%~49.5%)。亚组分析结果显示,横断面研究的血脂异常患病率(54.4%)高于队列研究(40.8%);采用美国指南诊断的患病率为(65.0%)高于中国2016版诊断标准(47.7%)和世界卫生组织标准(46.8%);调查时间显示2011~2016年(59.5%)高于2004~2010年(39.9%)和2017~2022年(44.7%);未接受抗逆转录治疗的患者患病率(62.6%)高于接受抗逆转录治疗的患者(46.7%);男性的血脂异常患病率(44.5%)高于女性(42.2%);CD4+细胞计数>500个/μl的血脂异常患病率(47.4%)高于<350个/μl(37.5%)和350~500个/μl(36.4%)。结论中国HIV/AIDS患者血脂异常的总患病率较高,受研究类型、调查时间、是否接受抗逆转录治疗、CD4+细胞计数水平、性别等因素的影响。Objective To systematically evaluate the prevalence of dyslipidemia among HIV/AIDS patients in China.Methods PubMed,Web of Science,Cochrane Library,Embase,CINAHL,CNKI,WanFang Data,VIP and CBM databases were searched for relevant studies from the inception of the database to December 2024.Two reviewers independently screened the literature,extracted data and evaluated the quality.Meta-analysis was performed using Stata 14.0.Results Fifteen studies were finally included involving 24,497 patients.The quality scores ranged from 7 to 9,indicating medium to high quality.The results showed that the overall prevalence of dyslipidemia in Chinese HIV/AIDS patients was 51.4%(95%CI 39.3%~63.4%),and the prevalence of high total cholesterolaemia was 8.7%(95%CI 4.7%~13.7%),hypertriacylglycerolaemia was 26.0%(95%CI 19.3%~33.4%),high low-density lipoprotein cholesterolaemia was 10.4%(95%CI 5.4%~16.8%),low high-density lipoprotein cholesterolaemia was 39.9%(95%CI 30.7%~49.5%).Subgroup analysis showed that the prevalence of dyslipidaemia was higher in cross-sectional studies(54.4%)than that in cohort studies(40.8%).In the diagnostic criteria,the prevalence based on American diagnostic standards(65.0%)was higher than that using the 2016 Chinese diagnostic criteria(47.7%)and the WHO standards(46.8%).Additionally,the prevalence was higher during 2011~2016(59.5%)than during 2004~2010(39.9%)and 2017~2022(44.7%).The prevalence of patients who did not receive antiretroviral therapy(62.6%)was higher than that of those who did(46.7%).The prevalence was higher in males(44.5%)than that in females(42.2%).Furthermore,patients with CD4+cell counts>500 cells/μl had a higher prevalence(47.4%)than those with<350 cells/μl(37.5%)and 350~500 cells/μl(36.4%).Conclusion The overall prevalence of dyslipidemia in Chinese HIV/AIDS patients is high and influenced by study type,investigative times,diagnostic criteria,received antiretroviral therapy or not,CD4+cell count level,and gender.

关 键 词：获得性免疫缺陷综合征 HIV 血脂异常 患病率 META分析 

分 类 号：R512.91[医药卫生—内科学]