植物苯丙素类天然产物生物合成研究进展  

Research progress on the biosynthesis of plant phenylpropanoids

作　　者：李凯薇 庄以彬[2,3,4] 唐俊 范晓光 毕慧萍[2,3,4] 刘涛[2,3,4] LI KaiWei;ZHUANG YiBin;TANG Jun;FAN XiaoGuang;BI HuiPing;LIU Tao(College of Biotechnology,Tianjin University of Science and Technolog,Tianjin 300457,China;Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;Key Laboratory of Engineering Biology for Low-carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,China)

机构地区：[1]天津科技大学生物工程学院,天津300457 [2]中国科学院天津工业生物技术研究所,天津300308 [3]中国科学院天津工业生物技术研究所低碳合成工程生物学重点实验室,天津300308 [4]国家合成生物技术创新中心,天津300308

出　　处：《中国科学:生命科学》2025年第4期647-660,共14页Scientia Sinica(Vitae)

基　　金：国家重点研发计划(批准号:2019YFA0905703);国家自然科学基金(批准号:31970065);天津市合成生物技术创新能力提升行动项目(批准号:TSBICIP-CXRC-056)资助。

摘　　要：苯丙素类是植物天然产物中的重要类型,具有多种生理活性,在营养保健、医药、化妆品等领域有广阔的应用前景.然而,植物中大部分苯丙素类天然产物生物合成途径尚未解析清楚,成为制约其研究与应用的瓶颈.近年来,基因组、转录组、蛋白组、代谢组等多组学技术的快速发展为解析植物次生代谢途径创造良好条件.解析苯丙素类天然产物生物合成机制将为植物中目标化合物的合成调控、异源高效合成提供关键基因资源.本文综述植物苯丙素类天然产物(不包括黄酮)生物合成方面的最新研究进展,重点包括一些有代表性的化合物如苯甲醛、水杨酸、菊苣酸、紫草素、香豆素,以及红景天苷、毛蕊花糖苷等,展望多组学分析等技术在植物苯丙素类天然产物合成途径解析方面的应用,以及微生物合成苯丙素类天然产物的工业应用前景,以期为苯丙素类天然产物的途径解析及微生物异源合成提供参考.Phenylpropanoids are important natural plant products with various physiological activities and have broad prospects for application in fields such as nutrition,healthcare,medicine,and cosmetics.However,the biosynthetic pathways of most of the phenylpropanoid natural plant products have not been fully elucidated,which is restricting research on them and their applications.The rapid development of multiomics technologies,such as genomics,transcriptomics,proteomics,and metabolomics,has facilitated the elucidation of plant secondary metabolite biosynthetic pathways.Elucidation of the biosynthetic mechanisms of plant phenylpropanoids will reveal key gene elements and enable the design of feasible ways for metabolic engineering and heterologous synthesis of target compounds.This article reviews the latest research progress in the biosynthesis of plant phenylpropanoids(excluding flavonoids),with a focus on some typical phenylpropanoids compounds,such as benzaldehyde,salicylic acid,chicoric acid,shikonin,coumarin,salidroside and verbascoside.Moreover,the review includes the application of multiomics analysis and other technologies in biosynthetic pathway analysis of plant phenylpropanoids,as well as the industrial application prospects of microbial synthesis of valuable phenylpropanoids.This review will provide a reference for elucidating biosynthetic pathways and heterologous synthesis of plant phenylpropanoids.

关 键 词：植物天然产物 苯丙素类 生物合成 

分 类 号：Q946[生物学—植物学]