运动康复改善冠状动脉微循环障碍的相关机制研究进展  

Research Progress on the Mechanism of Exercise Rehabilitation in Improving Coronary Microcirculation Disorder

作　　者：高桂英 胡阳[1] 张世益 孟怡 邓洁[1] GAO Guiying;HU Yang;ZHANG Shiyi;MENG Yi;DENG Jie(Department of General Medicine,Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,China)

机构地区：[1]昆明医科大学附属延安医院全科医学科,云南省昆明市650051

出　　处：《中国全科医学》2025年第20期2570-2576,共7页Chinese General Practice

基　　金：云南省卫生健康委员会医学后备人才培养计划(H-2019022);昆明市卫生科技人才培养项目暨“十百千”工程培养经费支持项目[2021-sw(省)-05]。

摘　　要：冠状动脉微循环障碍是指冠状前小动脉和小动脉结构和/或功能异常所致的临床综合征,与急性冠脉综合征、冠状动脉罪犯血管再通及心力衰竭等心血管疾病预后生存密切相关。作为心血管疾病预防和治疗的非药物干预手段,运动康复通过信号分子改善冠状动脉微循环障碍患者的内皮功能和氧化炎症刺激,恢复线粒体自噬水平,诱导血管周围脂肪组织功能恢复等。本文就运动康复干预冠状动脉微循环障碍的相关研究进展进行综述,旨在为运动康复治疗冠状动脉微循环障碍提供更多思路及参考。Coronary microcirculation disorder refers to the clinical syndrome caused by the abnormal structure and/or function of the precoronary arterioles and arterioles,which is closely related to the prognosis of cardiovascular diseases such as acute coronary syndrome,coronary offender vascular revascularization and heart failure.As a non-drug intervention for the prevention and treatment of cardiovascular diseases,exercise rehabilitation improves endothelial function and oxidative inflammation stimulation in patients with coronary microcirculation disorders through signaling molecules,restores mitochondrial autophagy level,and induces functional recovery of perivascular adipose tissue.This article reviewed the research progress of exercise rehabilitation intervention in coronary microcirculation disorder,aiming to provide more ideas and references for exercise rehabilitation treatment of coronary microcirculation disorder.

关 键 词：冠状动脉微循环障碍 运动康复 内皮功能障碍 线粒体自噬 血管周围脂肪组织 

分 类 号：R331.37[医药卫生—人体生理学]