限能量饮食联合高蛋白高膳食纤维代餐粉加益生菌方案在超重/肥胖成人中的应用效果  

Application effects of calorie-restricted diet combined with high-protein,high-dietary fiber meal replacement powder and probiotics in overweight/obese adults

作　　者：周谨[1] 田津 闫晓婧[1] 卢承前 王静[1] 颜伟[1] 杨莉[1] 殷婕[1] 胡宝玲 冯晓曼 张艳慧 陶黎 李增宁[3] Zhou Jin;Tian Jin;Yan Xiaojing;Lu Chengqian;Wang Jing;Yan Wei;Yang Li;Yin Jie;Hu Baoling;Feng Xiaoman;Zhang Yanhui;Tao Li;Li Zengning(Health Care Center,First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Beijing Jin De Health Technology Co.,LTD,Beijing 101214,China;Nutrition Department,First Hospital of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]河北医科大学第一医院健康管理中心,石家庄050031 [2]北京劲得健康科技有限公司,北京101214 [3]河北医科大学第一医院营养科,石家庄050031

出　　处：《中华健康管理学杂志》2025年第4期264-272,共9页Chinese Journal of Health Management

基　　金：国家重点研发计划(2020YFC2006304)。

摘　　要：目的分析限能量饮食联合高蛋白高膳食纤维代餐粉加益生菌方案在超重/肥胖成人中的应用效果。方法本研究为随机对照试验,连续选取2021年11月至2022年3月在河北医科大学第一医院健康管理中心进行体检的150例超重/肥胖成人为研究对象,采用随机数字表法分为联合组、高蛋白组和普通组(各50例)。3组研究对象均接受减重健康宣教+限能量膳食+代餐粉及益生菌(或益生菌安慰剂)干预,联合组给予高蛋白高膳食纤维代餐粉和益生菌,高蛋白组给予高蛋白代餐粉和益生菌安慰剂,普通组给予普通代餐粉和益生菌安慰剂。代餐粉35 g/袋,主要成分为含量各不相同的蛋白质、脂肪、碳水化合物、维生素和微量元素;益生菌粉和益生菌安慰剂均2 g/袋,益生菌粉主要成分为多种双歧杆菌、乳酸杆菌和辅料,益生菌安慰剂主要成分为辅料。代餐粉及益生菌粉或益生菌安慰剂每日2次,每次各1袋,共12周,结束后再随访4周。检测试验开始前(0周)及开始后第2、4、8、12、16周结束时的体重、体重指数、体脂量、腹围和臀围,计算各项指标变化率;检测第0周及第4、8、12周结束时的生化指标、微量元素和25-羟维生素D水平,并在第12周结束时进行产品评估问卷调查。由于各种原因中途出组19例,最终联合组46例、高蛋白组42例、普通组43例纳入分析。采用配对样本t检验、Kruskal-Wallis H检验、单因素方差分析和Mann-Whitney U检验比较3种干预方案的减重及维持效果、安全性及患者接受程度差异,分析限能量饮食联合高蛋白高膳食纤维代餐粉加益生菌方案在超重/肥胖成人的应用效果。结果纳入分析的131例超重/肥胖成人中,男性57例,女性74例,年龄(37.30±8.33)岁。第12周结束时,联合组、高蛋白组、普通组的体重指数[26.87(25.77,30.38)比29.61(27.96,33.09)kg/m^(2)、27.10(24.70,31.37)比29.40(27.20,34.17)kg/m^(2)、27.98(26.43ObjectiveTo assess the application effects of an energy-restricted diet combined with high-protein,high-dietary-fiber meal replacement powder and probiotics in overweight/obese adults.MethodsIt was a randomized controlled trial.A consecutive sample of 150 overweight/obese adults who underwent physical examinations at the Health Care Center of the First Hospital of Hebei Medical University between November 2021 and March 2022.The participants were randomly assigned into the combined group,the high-protein group,and the common group(50 participants per group)using a random number table method.All three groups of subjects received weight loss health education,energy-restricted diet,and interventions with meal replacement powder and probiotics(or probiotic placebo).The combined group was given high-protein and high-dietary fiber meal replacement powder and probiotics.The high-protein group was given high-protein meal replacement powder and probiotic placebo.The common group was given ordinary meal replacement powder and probiotic placebo.The meal replacement powder was packaged in 35 g per bag,with main components of varying amounts of protein,fat,carbohydrates,vitamins,and trace elements.Both the probiotic powder and the probiotic placebo came in 2 g sachets.The primary components of probiotic powder were various Bifidobacterium,Lactobacillus and excipients,while the main component of probiotic placebo was excipients.The meal replacement powder and the probiotic powder or probiotic placebo were taken twice a day for a total of 12 weeks,one sachet of each time,followed by a 4-week follow-up.The body weight,body mass index,body fat mass,abdominal circumference and hip circumference were measured before the trial(week 0)and at the end of weeks 2,4,8,12,and 16.The change rates of each indicator were calculated.Biochemical indicators,trace elements,and 25-hydroxyvitamin D levels were measured at the end of week 0,4,8,and 12.A product evaluation questionnaire was conducted at the end of week 12.A total of 19 cases dropped

关 键 词：超重 肥胖 成人 代餐粉 益生菌 限能量饮食 减重 

分 类 号：R589.2[医药卫生—内分泌]