脑出血动物模型的中西医临床病证特点分析  

Clinical Characteristics of Animal Models of Cerebral Hemorrhage in Traditional Chinese and Western Medicine

作　　者：王嘉 苗明三[1] 时博[1] WANG Jia;MIAO Mingsan;SHI Bo(Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中药药理与临床》2025年第2期84-89,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：岐黄学者(国中医药人教函2022-6);河南省重大专项(编号:221100310400);国家中医药管理局联合开放课题(编号:GZYKJS-2022-040-1);河南省国际合作重点项目(豫财科[2023]16号)。

摘　　要：目的:基于脑出血病的中西医诊断标准,对目前常见的脑出血动物模型进行归纳总结,以构建更加符合中西医临床病证特点的脑出血病动物模型。方法:以“脑出血”、“出血性卒中”、“中风”、“出血性脑血管病”、“蛛网膜下腔出血”、“脑溢血”、“动物模型”为关键词在中国知网、万方、维普、PubMed、Cochrane及SinoMed等数据库检索,依据中西临床诊断标准,对造模方法进行总结、归纳,评判优缺点、吻合度。结果:目前常见的脑出血动物模型中,主要有手术类、自发类、药物诱导类、多因素诱导类以及淀粉样脑血管病相关性动物模型五大类。结论:在模型评价中,多因素诱导法中的“肝阳暴亢证大鼠模型”、“痰热腑实证大鼠模型”、“应激法+双肾动脉夹闭法+胶原酶注入法”等方法造模的动物符合中医肝阳暴亢证、痰热腑实证,与中西医临床吻合度高。但动物模型评价标准尚未完善,限制了对该疾病的研究。本文在分析脑出血动物模型的优缺点及其与中西医临床特征的吻合度的同时提出相应的脑出血动物模型评价方法和改进方向,为进一步建立符合完善中西医临床病证特点的脑出血动物模型体系提供建议,使脑出血动物模型更贴近于临床,对脑出血的临床诊断与治疗起到一定作用。Objective:To establish the animal model of cerebral hemorrhage that is more in line with the clinical characteristics of this disease in traditional Chinese and Western medicine by reviewing the commonly used animal models of cerebral hemorrhage based on the diagnostic cri-teria of traditional Chinese and Western medicine for cerebral hemorrhage.Methods:With"cerebral hemorrhage","hemorrhagic stroke","stroke","hemorrhagic cerebrovascular disease","subarachnoid hemorrhage","intracerebral hemorrhage",and"animal model"as the key-words,CNKI,Wanfang Data,VIP,PubMed,Cochrane,and SinoMed were searched for the relevant articles.According to the clinical diagnos-tic standards of cerebral hemorrhage in traditional Chinese and Western medicine,the modeling methods were summarized,and the advanta-ges,disadvantages,and degree of agreement were evaluated.Results:Surgical,spontaneous,drug-induced,multifactorial induced,and amyloid deposition-induced animal models were the commonly used animal models of cerebral hemorrhage.Conclusion:In the model evaluation,the multifactorial induced animal models,such as the rat model with the syndrome of Ganyangbaokang(肝阳暴亢),the rat model with the syn-drome of Tanrefushi(痰热腑实),and the model established by the stress method+double renal artery clamping+collagenase injection,are consistent with corresponding traditional Chinese medicine(TCM)syndromes,demonstrating high degrees of agreement with the clinical char-acteristics of the disease in traditional Chinese and Western medicine.However,the evaluation criteria for the animal models are imperfect,which limits the TCM research on this disease.This article analyzes the advantages and disadvantages of the animal models of cerebral hemor-rhage and their degrees of agreement with clinical features of the disease in traditional Chinese and Western medicine,while proposing corre-sponding evaluation methods and improvement directions.It provides suggestions for establishing an animal model system for cerebral hemor-rhage based on the cl

关 键 词：脑出血 中风 动物模型 临床病证特点 

分 类 号：R255.2[医药卫生—中医内科学]