基于数据挖掘论玫瑰痤疮外用中药的用药规律研究  

Medication Rules of Chinese Medicines for External Application in Treating Acne Rosacea Based on Data Mining

作　　者：吴思琪 马梦茜 李亚琴 汪津禾 郎娜[1] WU Siqi;MA Mengxi;LI Yaqin;WANG Jinhe;LANG Na(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091)

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中药药理与临床》2025年第2期90-95,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：中国中医科学院科技创新工程项目(编号:CI2021A02317);首都临床特色诊疗技术研究及转化应用项目(编号:Z221100007422126)。

摘　　要：目的:基于数据挖掘技术探索玫瑰痤疮的外用中医药治疗方剂的用药特点和组方规律。方法:搜索建库-2023年2月知网、万方、维普三大中文数据库应用外用中药治疗玫瑰痤疮的相关文献,筛选后将处方中药数据录入Microsoft Excel 2016中进行频数统计,分析处方类型、使用方法以及中药的频次、分类、功效、四气、五味及归经,再利用IBM SPSS Modeler 18.1、IBM SPSS Statistics 25.0对数据进行关联规则分析和聚类分析,探索方剂组方特色、用药规律。结果:研究共纳入54首处方,涉及中药107味。其中,处方剂型以中药面膜粉剂为主,用水调后外敷;单味高频次药物按排名分别为:大黄、黄柏、百部、硫黄、生甘草、苦参、黄芩、马齿苋、蒲公英、蛇床子、白芷、苍术、野菊花,常用剂量多为15 g、30 g;中药类别主要为清热药、泻下药和化痰止咳平喘药;四气以寒、温、平居多;五味以苦、辛、甘为主;归经集中在肝、脾、胃、大肠、肺;关联规则得到常用药对组合前3位分别是大黄-硫黄、大黄-黄柏、蛇床子-苦参;系统聚类分析得到中药聚类组合4个。结论:玫瑰痤疮的外用中药多制成粉剂,用药以清热药为主,性味以苦寒为主,归经以肝经为主,为临床用药提供参考。Objective:To explore the medication characteristics and compatibility rules of Chinese medicines for external application in treating acne rosacea based on data mining.Methods:The articles about the external application of Chinese medicines for treating acne rosacea were re-trieved from CNKI,Wanfang Data,and VIP with the time interval from inception to February 2023.After screening,the Chinese medicines used in the prescriptions were organized in Microsoft Excel 2016.The prescription type and application method,and the frequency,category,effects,natures,tastes,and channel tropism of the Chinese medicines were analyzed.IBM SPSS Modeler 18.1 and IBM SPSS Statistics 25.0 were then used for cluster analysis and association rule analysis to explore the characteristics and Medication Rules of prescriptions.Results:A total of 54 prescriptions involving 107 Chinese medicines were included in this study.The prescriptions were mainly prepared into powder,which was applied externally on face after being mixed with water.The frequency of Chinese medicines was in a descending order of Dahuang(大黄),Huangbai(黄柏),Baibu(百部),Liuhuang(硫黄),Shenggancao(生甘草),Kushen(苦参),Huangqin(黄芩),Machixian(马齿苋),Pugongying(蒲公英),Shechuangzi(蛇床子),Baizhi(白芷),Cangzhu(苍术),and Yejuhua(野菊花).The commonly used do-ses of the high-frequency medicines were 15 g and 30 g.Qingre(清热),Xiexia(泻下),and relieving phlegm and resolving cough and asth-ma medicines were mainly used.The medicines mainly had the tastes of Ku(苦),Xin(辛),and Gan(甘),the natures of Han(寒),Wen(温),and Ping(平),and tropism to Ganjing(肝经),Pijing(脾经),Weijing(胃经),Dachangjing(大肠经),and Feijing(肺经).The association rule analysis revealed that the top 3 medicine pairs were Dahuang-Liuhuang,Dahuang-Huangbai,and Shechuangzi-Kushen.The cluster analysis yielded 4 medicine groups.Conclusion:The prescriptions for treating rosacea were mostly prepared into powder for external application.Qingre medicines were commo

关 键 词：玫瑰痤疮 中药 外用 用药特色 数据挖掘 

分 类 号：R275.9[医药卫生—中西医结合]