滋阴降火方辅助治疗特发性中枢性性早熟阴虚火旺型女童69例临床观察  

Clinical observation on 69 cases of female children with idiopathic central precocious puberty of yin deficiency and excessive fire pattern treated with Ziyin Xiehuo Fang(滋阴泻火方)as adjuvant therapy

作　　者：王婷 姜薇 毛中美[1] 游敏 姜帅[1] WANG Ting;JIANG Wei;MAO Zhongmei;YOU Min;JIANG Shuai(Department of Acupuncture,Moxibustion and Physical Therapy,Quzhou People's Hospital,Quzhou,Zhejiang,324000,China)

机构地区：[1]衢州市人民医院针灸理疗科,浙江衢州324000

出　　处：《中医儿科杂志》2025年第2期61-66,共6页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察滋阴降火方辅助治疗特发性中枢性性早熟阴虚火旺型女童的临床疗效。方法选取2020年1月至2022年12月于衢州市人民医院针灸理疗科治疗的特发性中枢性性早熟阴虚火旺型女童138例,采用随机数字表法分为对照组和治疗组,各69例。对照组予醋酸亮丙瑞林缓释微球肌内注射,治疗组在对照组治疗方法的基础上口服滋阴降火方。2组均治疗6个月后统计疗效。结果治疗前2组的血清25-羟维生素D_(3)[25(OH)D_(3)]、五羟色胺(5-HT)、N端骨钙素(N-MID)、胰岛素样生长因子-1(IGF-1)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的血清5-HT、N-MID、IGF-1水平显著降低,25(OH)D_(3)水平显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或降低更显著(P<0.05)。治疗前2组的卵泡刺激素(FSH)、雌二醇(E2)、促黄体生成素(LH)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的上述指标水平均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗前,2组的身高、骨龄指数及中医症状总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组的身高均显著升高,骨龄指数及中医症状总积分均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或降低更显著(P<0.05)。治疗前,2组的卵巢体积、子宫体积及乳核直径比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的上述指标均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗组的总有效率为94.20%(65/69),显著高于对照组的79.71%(55/69),2组比较,差异有统计学意义(P<0.05)。结论滋阴降火方辅助治疗特发性中枢性性早熟阴虚火旺型女童疗效确切,可显著改善临床症状,促进骨骼发育,降低性激素水平,减缓第二性征发育Objective To observe the clinical efficacy of Ziyin Xiehuo Fang(滋阴泻火方)as adjuvant therapy in female children with idiopathic central precocious puberty(ICPP)of yin deficiency and excessive fire pattern.Methods A total of 138 female children with ICPP of yin deficiency and excessive fire pattern,treated in the Department of Acupuncture,Moxibustion and Physical Therapy of Quzhou People’s Hospital from January 2020 to December 2022,were enrolled and randomly divided into a control group and a treatment group,with 69 cases in each.The control group received intramuscular injection of leuprolide acetate microspheres,while the treatment group received oral Ziyin Xiehuo Fang on the basis of the control group’s treatment.The therapeutic effects were evaluated after 6 months of treatment in both groups.Results Before treatment,there were no statistically significant differences in serum levels of 25-hydroxy vitamin D_(3)[25(OH)D_(3)],5-hydroxytryptamine(5-HT),N-terminal mid-fragment of osteocalcin(N-MID),and insulin-like growth factor-1(IGF-1)between the two groups(P>0.05),indicating comparability.After treatment,the serum levels of 5-HT,N-MID,and IGF-1 were significantly decreased,while the level of 25(OH)D_(3)was significantly increased in both groups,with statistically significant differences compared with those before treatment(P<0.05).The increase or decrease was more significant in the treatment group(P<0.05).Before treatment,there were no statistically significant differences in follicle-stimulating hormone(FSH),estradiol(E2),and luteinizing hormone(LH)levels between the two groups(P>0.05),indicating comparability.After treatment,the levels of these indicators were significantly decreased in both groups,with statistically significant differences compared with those before treatment(P<0.05).The decrease was more significant in the treatment group(P<0.05).Before treatment,there were no statistically significant differences in actual height,bone age index,and total score of traditional Chinese medicine(T

关 键 词：特发性中枢性性早熟 女童 阴虚火旺型 滋阴降火方 临床观察 

分 类 号：R725.8[医药卫生—儿科]