温肺止流丹合苍耳子散加减辅助治疗儿童慢性鼻窦炎肺气虚寒型39例临床观察  

Clinical observation on 39 children with chronic rhinosinusitis of lung qi deficiency and cold type treated with modified Wenfei Zhiliu Dan(温肺止流丹)combined with Cang'erzi San(苍耳子散)as adjuvant therapy

作　　者：陈华英 CHEN Huaying(Pediatrics Department,Dongyang Red Cross Hospital,Dongyang,Zhejiang,322100,China)

机构地区：[1]东阳市红会医院儿科,浙江东阳322100

出　　处：《中医儿科杂志》2025年第2期66-70,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察温肺止流丹合苍耳子散加减辅助治疗儿童慢性鼻窦炎(CRS)肺气虚寒型的临床疗效。方法选取2020年1月至2022年1月东阳市红会医院儿科收治的CRS肺气虚寒型患儿82例,采用随机数字表法分为治疗组和对照组,各41例。治疗期间,治疗组脱落2例,对照组脱落1例,最终治疗组39例,对照组40例。对照组给予罗红霉素颗粒口服及糠酸莫米松鼻喷雾剂喷鼻治疗;治疗组先给予罗红霉素颗粒加温肺止流丹合苍耳子散加减口服治疗2周后停用,再给予糠酸莫米松鼻喷雾剂喷鼻6周治疗。2组均治疗8周后统计临床疗效,比较视觉模拟评分法(VAS)评分、鼻窦CT检查Lund-Mackay评分以及3个月内的复发率。结果治疗组总有效率为92.31%(36/39),显著高于对照组的55.00%(22/40),2组比较,差异有统计学意义(P<0.01)。治疗前,2组鼻塞、流脓涕、咳嗽、打鼾和总评分以及鼻窦CT Lund-Mackey评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述评分较治疗前均降低,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组降低更显著(P<0.01)。治疗组复发率为22.22%(8/36),对照组为54.54%(12/22),2组比较,差异有统计学意义(P<0.05)。结论温肺止流丹合苍耳子散加减辅助治疗儿童CRS肺气虚寒型疗效显著,可显著改善患儿临床症状,降低鼻窦CT Lund-Mackey评分,且复发率较低,值得临床推广应用。ObjectiveTo observe the clinical efficacy of Wenfei Zhiliu Dan(温肺止流丹)combined with modified Cang'erzi San(苍耳子散)in children with chronic rhinosinusitis(CRS)of lung qi deficiency and cold type as adjuvant therapy.MethodsA total of 82 pediatric patients with CRS of lung qi deficiency and cold type admitted to the Pediatrics Department of Dongyang Red Cross Hospital from January 2020 to January2022 were selected and randomly divided into a treatment group and a control group,with 41 patients in each group.During the treatment period,2 patients dropped out in the treatment group and 1 in the control group,resulting in a final count of 39 patients in the treatment group and 40 in the control group.The control group received oral Erythromycin granules and intranasal Fluticasone Furoate Nasal Spray.The treatment group first received oral Erythromycin granules combined with modified Wenfei Zhiliu Dan and Cang'erzi San for 2 weeks,followed by a discontinuation and then 6 weeks of intranasal Fluticasone Furoate Nasal Spray.The clinical efficacy was evaluated after 8 weeks of treatment in both groups,and comparisons were made in terms of visual analog scale(VAS)scores,Lund-Mackay scores from sinus CT scans,and recurrence rates within 3 months.ResultsThe total effective rate in the treatment group was 92.31%(36/39),significantly higher than the55.00%(22/40)in the control group,with a statistically significant difference between the two groups(P<0.01).Before treatment,there were no statistically significant differences in nasal obstruction,purulent rhinorrhea,cough,snoring,total scores,and Lund-Mackey scores from sinus CT scans between the two groups(P>0.05),indicating comparability.After treatment,the above scores decreased in both groups compared with those before treatment,with statistically significant differences compared with the pre-treatment scores within the same group(P<0.01),and the decrease was more significant in the treatment group(P<0.01).The recurrence rate was 22.22%(8/36)in the treatment gro

关 键 词：儿童慢性鼻窦炎 肺气虚寒型 温肺止流丹 苍耳子散 临床观察 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]