自噬与心房颤动发生和发展关系的研究进展  

Research progress on the relationship between autophagy and the occurrence and development of atrial fibrillation

作　　者：李嘉菲 张朕豪 王硕 崔永春[1] 叶振 LI Jiafei;ZHANG Zhenhao;WANG Shuo;CUI Yongchun;YE Zhen(Bejing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials,Animal Experimental Center,Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 102300,China;Department of Pharmacy,Jiangsu Province(Suqian)Hospital,Suqian 223800,Jiangsu,China)

机构地区：[1]北京协和医学院心血管疾病国家重点实验室、国家心血管病中心、心血管植人材料临床前研究评价北京市重点实验室、中国医学科学院阜外医院、动物实验中心,北京102300 [2]江苏省人民医院宿迁医院药学部,江苏宿迁223800

出　　处：《中国分子心脏病学杂志》2025年第1期6654-6661,共8页Molecular Cardiology of China

基　　金：宿迁市科技计划自然科学基金(K202320,2023-SQKJ01)。

摘　　要：心房颤动(AF)是一种常见的心律失常性疾病,患病风险随着年龄增长而增加。AF的发生机制复杂,涉及心房结构重构(如心房纤维化、心肌细胞肥大等)、电重构(如离子通道异常、缝隙连接蛋白功能障碍等)及其他特殊重构(如功能重构、免疫重构等)。自噬的平衡对维持细胞稳态至关重要,其过度激活或抑制均可促进AF发展。自噬水平的异常可促进心房结构重构和电重构,而影响自噬通量的因素主要包括年龄、内质网应激、炎症及代谢紊乱。作为一种特殊的自噬形式,线粒体自噬在AF的形成和发展过程中也起着重要作用。针对自噬过程的干预可能为AF治疗开辟新途径,如4-苯基丁酸钠盐可抑制内质网应激相关的自噬,槲皮素可抑制心肌纤维化并改善心房重构。深入研究自噬与AF发生和发展的关系,对揭示AF发病机制和探索新的治疗策略具有重要意义。Atrial fibrillation(AF),a prevalent cardiac arrhythmia,exhibits a propensity for increased incidence with advancing age.The mechanism of AF is complex,involving atrial structural remodeling,which include atrial fibrosis and cardiomyocyte hypertrophy,alongside electrical remodeling characterized by ion channel abnormalities and connexin dysfunction.Additionally,the mechanism involves other distinct forms of remodeling,such as functional remodeling and immune remodeling.The balance of autophagy is crucial for cellular homeostasis,and its overactivation or inhibition may promote the development of AF.Disrupted autophagy contributes to atrial remodeling,influenced by age,endoplasmic reticulum stress,inflammation,and metabolic disorders.Mitophagy,a specific type of autophagy,plays an important role in the formation and development of AF.Targeting autophagy may lead to new treatments for AF.For instance,4-PBA can suppress autophagy linked to ER stress,while quercetin can prevent myocardial fibrosis and improve atrial remodeling.Exploring the link between autophagy and AF is crucial for understanding its causes and developing new treatments.

关 键 词：心房颤动 自噬 结构重构 电重构 治疗 

分 类 号：R541.7[医药卫生—心血管疾病]