阿司匹林联合氯吡格雷在稳定型冠心病患者经皮冠状动脉介入术后的应用效果  

Effect of Aspirin Combined with Clopidogrel in Patients with Stable Coronary Heart Disease after Percutaneous Coronary Intervention

作　　者：付金梅 李小瑜 马利贤 Fu Jinmei;Li Xiaoyu;Ma Lixian(th Hospital of Chinese People's Liberation Army Joint Logistic Support Force,Nanning 530000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]中国人民解放军联勤保障部队第九二三医院,广西壮族自治区南宁530000

出　　处：《中外医药研究》2025年第10期31-33,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析稳定型冠心病患者经皮冠状动脉介入(PCI)术后应用阿司匹林与氯吡格雷的效果。方法:选取2023年3—12月于中国人民解放军联勤保障部队第九二三医院接受PCI治疗的稳定型冠心病患者73例纳入研究,采用信封法随机分成对照组(n=35)及观察组(n=38)。对照组PCI术后应用阿司匹林治疗,观察组PCI术后应用阿司匹林与氯吡格雷联合治疗。比较两组心功能指标、冠状动脉血流储备功能及术后支架内再狭窄(ISR)发生率。结果:治疗后,两组左室舒张末期内径、左室收缩末期内径缩小,左室射血分数升高(P<0.05);两组左室舒张末期内径、左室收缩末期内径、左室射血分数比较,无统计学差异(P>0.05)。治疗后,两组冠状动脉血流储备分数、峰值血流速度增加,观察组峰值血流速度快于对照组(P<0.05);两组冠状动脉血流储备分数比较,无统计学差异(P>0.05)。观察组术后12个月ISR发生率低于对照组(P=0.040)。结论:相较于单独应用阿司匹林,阿司匹林与氯吡格雷联合应用能够降低稳定型冠心病患者PCI术后ISR的发生风险,改善患者冠状动脉血流储备功能,且对心功能无不良影响。Objective:To analyze the effects of aspirin and clopidogrel after percutaneous coronary intervention(PCI)in patients with stable coronary heart disease.Methods:A total of seventy-three patients with stable coronary heart disease who received PCI treatment at 923th Hospital of Chinese People's Liberation Army Joint Logistic Support Force from March to December 2023 were selected for the study,and randomly divided into control group(n=35)and observation group(n=38)by envelope method.The control group was treated with aspirin after PCI,and the observation group was treated with aspirin combined with clopidogrel after PCI.Cardiac function,coronary blood reserve function and the incidence of intrastent restenosis(ISR)were compared between the two groups.Results:After treatment,left ventricular end-diastolic diameter and left ventricular end-systolic diameter decreased,and left ventricular ejection fraction increased(P<0.05).There were no significant differences in left ventricular end-diastolic diameter,left ventricular end-systolic diameter and left ventricular ejection fraction between the two groups(P>0.05).After treatment,coronary flow reserve fraction and peak blood flow velocity increased in both groups,and the peak blood flow velocity in observation group was faster than that in control group(P<0.05).There was no significant difference in coronary flow reserve between the two groups(P>0.05).The incidence of ISR 12 months after operation in the observation group was lower than that in the control group(P=0.040).Conclusion:Compared with aspirin alone,aspirin combined with clopidogrel can reduce the risk of ISR after PCI in patients with stable coronary heart disease,improve the function of coronary blood reserve,and have no adverse effects on cardiac function.

关 键 词：支架内再狭窄 稳定型冠心病 经皮冠状动脉介入术 氯吡格雷 阿司匹林 

分 类 号：R541.4[医药卫生—心血管疾病]