紫杉醇药物涂层球囊与普通球囊在下肢动脉硬化闭塞症患者经皮腔内血管成形术中的应用效果  

Application of Paclitaxel Drug-coated Balloon and Conventional Balloon in Percutaneous Transluminal Angioplasty of Patients with Lower Extremity Arteriosclerotic Obliterans

作　　者：吉中蛟 Ji Zhongjiao(Yancheng First People's Hospital,Yancheng 224000,Jiangsu Province,China)

机构地区：[1]盐城市第一人民医院,江苏盐城224000

出　　处：《中外医药研究》2025年第10期46-48,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨紫杉醇药物涂层球囊与普通球囊在下肢动脉硬化闭塞症患者经皮腔内血管成形术中的应用效果。方法:选择2020年3月—2023年6月于盐城市第一人民医院接受经皮腔内血管成形术的下肢动脉硬化闭塞症患者80例为研究对象,随机分为对照组(使用普通球囊)和观察组(使用紫杉醇药物涂层球囊),各40例。对比两组术后并发症发生情况、踝肱指数、最小管腔直径、晚期管腔丢失量、再狭窄率。结果:观察组术后并发症总发生率低于对照组(P=0.048);术后6、12个月,两组踝肱指数高于术前,观察组高于对照组(P<0.05);术后即刻、术后12个月,两组最小管腔直径大于术前,观察组大于对照组(P<0.05);术后6、12个月,观察组晚期管腔丢失量小于对照组(P<0.001);术后12个月,观察组再狭窄率低于对照组(P=0.025)。结论:紫杉醇药物涂层球囊在下肢动脉硬化闭塞症患者经皮腔内血管成形术中的应用效果更好,能减少术后并发症,提高踝肱指数,增加管腔直径,降低远期再狭窄率。Objective:To investigate the effect of paclitaxel drug-coated balloon and conventional balloon in percutaneous transluminal angioplasty in patients with lower extremity arteriosclerotic obliterans.Methods:A total of eighty patients with lower extremity arteriosclerotic obliterans disease who received percutaneous endovascular angioplasty in Yancheng First People's Hospital from March 2020 to June 2023 were selected as the study objects,and were randomly divided into control group(using conventional balloon)and observation group(using paclitaxel drug-coated balloon),with forty cases in each group.The incidence of postoperative complications,ankle-brachial index,minimum lumen diameter,late lumen loss and restenosis rate were compared between the two groups.Results:The incidence of postoperative complications in the observation group was lower than that in the control group(P=0.048).At 6 and 12 months after operation,the ankle-brachial index in two groups was higher than before operation,and the observation group was higher than the control group(P<0.05).Immediately after surgery and 12 months after surgery,the minimum lumen diameter in two groups was greater than before surgery,and the observation group was greater than the control group(P<0.05).At 6 and 12 months after operation,the amount of late lumen loss in the observation group was less than that in the control group(P<0.001).At 12 months after operation,the restenosis rate in observation group was lower than that in control group(P=0.025).Conclusion:The application of paclitaxel drug-coated balloon in lower extremity arteriosclerotic obliterans patients with percutaneous transluminal angioplasty is better,which can reduce postoperative complications,increase ankle-brachial index,increase lumen diameter,and reduce long-term restenosis rate.

关 键 词：下肢动脉硬化闭塞症 药物涂层球囊 普通球囊 经皮腔内血管成形术 

分 类 号：R654.4[医药卫生—外科学]